Is Chondroitin Sulfate Sodium compatible with breastfeeding? Do we have alternatives for Chondroitin Sulfate Sodium?

Chondroitin Sulfate Sodium

September 19, 2016 (Very Low Risk)

Copolymer which is found in nature that is obtained from cartilage of various terrestrial or marine animals and used in the treatment of osteoarthritis.
It is a mucopolysaccharide which is formed by polymers of glycosaminoglycan (GAG) and devoid of toxicity.

It is presented in the human body and breast milk, with the highest concentration in the milk of mothers of preterm babies. (Coppa 2012).
Half concentration of GAG in the milk is contained as chondroitin sulfate with anti-infectious properties; among others, it protects the gastrointestinal tract of infants against infections (Maccari 2016).
Its concentration is not affected by Holder pasteurization method of breast milk.
Changes on the composition of chondroitin sulfate in the milk have been detected in cases of breast cancer.

Because a high molecular weight the passage of significant amounts into milk is highly unlikely.
Its low oral bioavailability hinders the passage from ingested milk to the infant plasma.

Alternatives

We do not have alternatives for Chondroitin Sulfate Sodium since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • Хондроитин Сульфат Натрия (Cyrillic)
  • コンドロイチン硫酸エステルナトリウム (Japanese)
  • (C14H19NO14SNa2)n (Molecular formula)

References

  1. Coppa GV, Facinelli B, Magi G, Marini E, Zampini L, Mantovani V, Galeazzi T, Padella L, Marchesiello RL, Santoro L, Coscia A, Peila C, Volpi N, Gabrielli O. Human milk glycosaminoglycans inhibit in vitro the adhesion of Escherichia coli and Salmonella fyris to human intestinal cells. Pediatr Res. 2016Abstract
  2. Maccari F, Mantovani V, Gabrielli O, Carlucci A, Zampini L, Galeazzi T, Galeotti F, Coppa GV, Volpi N. Metabolic fate of milk glycosaminoglycans in breastfed and formula fed newborns. Glycoconj J. 2016Abstract
  3. AEMPS. Condroitín. Ficha técnica. 2016 Full text (in our servers)
  4. Coscia A, Peila C, Bertino E, Coppa GV, Moro GE, Gabrielli O, Zampini L, Galeazzi T, Maccari F, Volpi N. Effect of holder pasteurisation on human milk glycosaminoglycans. J Pediatr Gastroenterol Nutr. 2015Abstract
  5. Volpi N, Gabrielli O, Carlucci A, Zampini L, Santoro L, Padella L, Marchesello RL, Maccari F, Coppa GV. Human milk glycosaminoglycans in feces of breastfed newborns: preliminary structural elucidation and possible biological role. Breastfeed Med. 2014Abstract
  6. Newburg DS. Glycobiology of human milk. Biochemistry (Mosc). 2013Abstract
  7. AESAN. Informe del Comité Científico de la Agencia Española de Seguridad Alimentaria y Nutrición (AESAN) sobre condiciones de uso de determinadas sustancias distintas de vitaminas, minerales y plantas para ser empleadas en complementos alimenticios - 1. Revista del comité científico nº 17. 2012 Full text (in our servers)
  8. Coppa GV, Gabrielli O, Zampini L, Galeazzi T, Maccari F, Buzzega D, Galeotti F, Bertino E, Volpi N. Glycosaminoglycan content in term and preterm milk during the first month of lactation. Neonatology. 2012Abstract
  9. Coppa GV, Gabrielli O, Buzzega D, Zampini L, Galeazzi T, Maccari F, Bertino E, Volpi N. Composition and structure elucidation of human milk glycosaminoglycans. Glycobiology. 2011Abstract
  10. Mannello F, Maccari F, Santinelli A, Volpi N. Chondroitin sulfate structure is modified in human milk produced by breast affected by invasive carcinoma. Breast. 2011Abstract
  11. Viveros-Rogel M, Soto-Ramirez L, Chaturvedi P, Newburg DS, Ruiz-Palacios GM. Inhibition of HIV-1 infection in vitro by human milk sulfated glycolipids and glycosaminoglycans. Adv Exp Med Biol. 2004Abstract
  12. Newburg DS. Human milk glycoconjugates that inhibit pathogens. Curr Med Chem. 1999Abstract
  13. Newburg DS. Oligosaccharides and glycoconjugates in human milk: their role in host defense. J Mammary Gland Biol Neoplasia. 1996Abstract
  14. Newburg DS, Linhardt RJ, Ampofo SA, Yolken RH. Human milk glycosaminoglycans inhibit HIV glycoprotein gp120 binding to its host cell CD4 receptor. J Nutr. 1995Abstract
  15. Sekine H, Ohno T, Kufe DW. Purification and characterization of a high molecular weight glycoprotein detectable in human milk and breast carcinomas. J Immunol. 1985Abstract