Is Fesoterodine compatible with breastfeeding? Do we have alternatives for Fesoterodine?

Fesoterodine

September 19, 2016 (Low Risk)

Antimuscarinic agent with atropine-like action. It is metabolized in Tolterodine

At latest update no published data on excretion into breast milk were found.

Until more published data on this drug in relation to breastfeeding is available, a known safer alternative as Tolterodine should be preferred with more favorable pharmacokinetics characteristics for lactation (e.g. high protein-binding capacity, faster elimination and lower oral bioavailability), particularly during the neonatal period and prematurity case.

Take as smallest dose as possible and avoid long-term use since anticholinergics can reduce milk production.

Monitoring anticholinergic symptoms in infants (dry mouth, constipation ..) is warranted.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Fesoterodine Fumarate

Writings

  • فيزوتيرونيد (Arabic)
  • Фезотеродин (Cyrillic)
  • 非索罗定 (Chinese)
  • フェソテロジン (Japanese)
  • C26H37NO3 (Molecular formula)

References

  1. EMA. Fesoterodina. Ficha técnica. 2014 Full text (in our servers)
  2. EMA. Fesoterodine. Drug Summary. 2014 Full text (in our servers)
  3. Bizzarro A, Iannucci F, Tolino A, Soricelli A, Guarino G, Verdoliva A. Inhibiting effect of atropine on prolactin blood levels after stimulation with TRH. Clin Exp Obstet Gynecol. 1980Abstract