Is Protamine Sulphate compatible with breastfeeding? Do we have alternatives for Protamine Sulphate?

Protamine Sulphate

August 12, 2014 (Low Risk)

Sperm protein of salmonide fish that may be used as heparin antidote (neutralizing effect by forming non-active stable complexes), and, as a drug to delay absorption of Insulin (NPH Insulin). Due to its protein structure a trespass to breast milk, or, oral absorption is highly unlikely.


We do not have alternatives for Protamine Sulphate.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.


  1. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)