Is Trientine Dihydrochloride compatible with breastfeeding? Do we have alternatives for Trientine Dihydrochloride?

Trientine Dihydrochloride

June 17, 2017 (Low Risk)

Copper chelator used in the treatment of Wilson's disease.

It is excreted in breast milk in clinically insignificant amounts (undetectable levels: Izumi 2012).

Copper and zinc levels in breastmilk of mothers treated with penicillamine, trientine or zinc are normal (Izumi 2012).

Oral bioavailability, which is very low during periods of fasting, is practically non-existent in the presence of food, especially milk, so it would be very difficult to pass into the infant plasma from the ingested breast milk (PDR 2016).

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • TETA
  • Triethylenetetramine Dihydrochloride

Writings

  • τριεντίνη διϋδροχλωρική (Greek)
  • Триентина Дигидрохлорид (Cyrillic)
  • 塩酸トリエンチン (Japanese)
  • C6H18N4,2HCl (Molecular formula)

Drug trade names

References

  1. PDR. Trientine hydrochloride. Drug Summary. 2016 Full text (link to original source) Full text (in our servers)
  2. Izumi Y. Can mothers with Wilson's disease give her breast milk to their infant? Teikyo Med J. 2012;35:17-24. 2012 Full text (link to original source) Full text (in our servers)