Is 5-Aminolevulinic Acid compatible with breastfeeding? Do we have alternatives for 5-Aminolevulinic Acid?

5-Aminolevulinic Acid

September 26, 2014 (Low Risk)

It is locally used together with photo-dynamic therapy (especial blue light) as a treatment of Actinic Dermatitis and Basocelular Carcinoma.

At latest update, relevant information on excretion into breast milk was not found.

Absorption through the skin is very low (0.26 % of administered dose), hence, a low or non-significant level in the mother's plasma should be expected.

In case that a complete elimination of drug would be desired, a time period equivalent to ten times a half-life (Mean time) should be observed after drug administration to resume breastfeeding.

In this case it would be equal to 8-10 hours.

In the mean while, pump-and-dump regularly to maintain milk production.

Do not apply it on the breast or cleanse it thoroughly to keep the baby from swallowing.


We do not have alternatives for 5-Aminolevulinic Acid.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.


  • 5-ALA
  • Methyl Aminolaevulinate Hydrochloride
  • アミノレブリン酸塩酸塩


  1. EMEA. Ácido 5-aminolevulínico. Ficha técnica 2011 Full text (in our servers)
  2. Sandberg C, Halldin CB, Ericson MB, Larkö O, Krogstad AL, Wennberg AM. Bioavailability of aminolaevulinic acid and methylaminolaevulinate in basal cell carcinomas: a perfusion study using microdialysis in vivo. Br J Dermatol. 2008Abstract
  3. McLoone N, Donnelly RF, Walsh M, Dolan OM, McLoone S, McKenna K, McCarron PA. Aminolaevulinic acid diffusion characteristics in 'in vitro' normal human skin and actinic keratosis: implications for topical photodynamic therapy. Photodermatol Photoimmunol Photomed. 2008Abstract
  4. New Zealand Datasheet. Methyl aminolevulinate. Drug Summary. 2008 Full text (in our servers)
  5. SNS. Aminolevulinato de metilo (ALM). Información Terapéutica. 2005 Full text (in our servers)