Is Acebutolol compatible with breastfeeding? Do we have alternatives for Acebutolol?

Acebutolol

November 8, 2014 (High Risk)

Drug is secreted in high amount into breast milk.

Several cases have been published that did not report side effects in nursing babies, however, hypotension, bradicardia and tachypnea were found in one newborn.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

References

  1. Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018Abstract
  2. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. 2013Abstract
  3. Ghanem FA, Movahed A. Use of antihypertensive drugs during pregnancy and lactation. Cardiovasc Ther. 2008Abstract Full text (link to original source) Full text (in our servers)
  4. Hale TW. Medications in breastfeeding mothers of preterm infants. Pediatr Ann. 2003Abstract
  5. Eidelman AI, Schimmel MS. Drugs and breast milk. Pediatrics. 1995Abstract
  6. Boutroy MJ, Bianchetti G, Dubruc C, Vert P, Morselli PL. To nurse when receiving acebutolol: is it dangerous for the neonate? Eur J Clin Pharmacol. 1986Abstract
  7. Riant P, Urien S, Albengres E, Duche JC, Tillement JP. High plasma protein binding as a parameter in the selection of betablockers for lactating women. Biochem Pharmacol. 1986Abstract