Is Acitretin compatible with breastfeeding? Do we have alternatives for Acitretin?

Acitretin

June 30, 2015 (High Risk)

Synthetic retinoid derivated from vitamin A.

Despite a low amount secreted through the breast milk (<2% of the equivalent maternal dose), some authorities think that product's toxicity justifies to avoid it during breastfeeding.

American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.

Alternatives

We do not have alternatives for Acitretin.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Etretin

Writings

  • أسيتريتين (Arabic)
  • Ацитретин (Cyrillic)
  • 阿维A (Chinese)
  • シトレチン (Japanese)

References

  1. Mervic L. Management of moderate to severe plaque psoriasis in pregnancy and lactation in the era of biologics. Acta Dermatovenerol Alp Pannonica Adriat. 2014Abstract Full text (link to original source) Full text (in our servers)
  2. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014Abstract
  3. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001Abstract Full text (link to original source) Full text (in our servers)
  4. Takizawa S, Fukatsu N, Horii I, Fujii T. Effect of etretinate (aromatic retinoid) treatment during gestation and lactation periods on viability and somatic growth in F1 rats. J Toxicol Sci. 1994Abstract
  5. Rollman O, Pihl-Lundin I. Acitretin excretion into human breast milk. Acta Derm Venereol. 1990Abstract
  6. Fleishaker JC, Desai N, McNamara PJ. Possible effect of lactational period on the milk-to-plasma drug concentration ratio in lactating women: results of an in vitro evaluation. J Pharm Sci. 1989Abstract