Is Alefacept compatible with breastfeeding? Do we have alternatives for Alefacept?


December 19, 2013 (Low Risk)

Fusion protein used for treatment of Psoriasis.

Because a high molecular weight excretion into breast milk must be minimal or nil.

Protein structure renders gastro-intestinal absorption unlikely.


We do not have alternatives for Alefacept.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Drug trade names


  1. Vaishnaw AK, TenHoor CN. Pharmacokinetics, biologic activity, and tolerability of alefacept by intravenous and intramuscular administration. J Pharmacokinet Pharmacodyn. 2002Abstract