Is Aliskiren compatible with breastfeeding? Do we have alternatives for Aliskiren?

Aliskiren

June 30, 2015 (Low Risk)

At latest update, relevant information on excretion into breast milk was not found.

Because of pharmacokinetic data (wide distribution volume and moderately high molecular weight) excretion into breast milk in significant quantity seems to be unlikely. Based on a low oral bioavailability, concentration in the infant's plasma should be nil or low, except in premature and newborn infants with a increased intestinal absorption capacity.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • Алискирена Фумарат (Cyrillic)
  • アリスキレンフマル酸塩 (Japanese)

Drug trade names

References

  1. EMEA. Aliskireno. Ficha técnica. 2012 Full text (in our servers)
  2. Belda-Rustarazo S, Vallejo-Rodríguez I, Molina-Carballo A, Cabeza Barrera J. Tratamiento de rescate con aliskiren en\ hipertensión maligna familiar en un\ lactante.\ [Salvage therapy with aliskiren in malignant familial hypertension in a breast-fed baby]. Farm Hosp. 2011Abstract Full text (in our servers)
  3. Belda-Rustarazo S, Vallejo-Rodríguez I, Molina-Carballo A, Cabeza Barrera J. [Salvage therapy with aliskiren in malignant familial hypertension in a breast-fed baby]. Farm Hosp. 2011Abstract
  4. Waldmeier F, Glaenzel U, Wirz B, Oberer L, Schmid D, Seiberling M, Valencia J, Riviere GJ, End P, Vaidyanathan S. Absorption, distribution, metabolism, and elimination of the direct renin inhibitor aliskiren in healthy volunteers. Drug Metab Dispos. 2007Abstract Full text (in our servers)
  5. Vaidyanathan S, Jermany J, Yeh C, Bizot MN, Camisasca R. Aliskiren, a novel orally effective renin inhibitor, exhibits similar pharmacokinetics and pharmacodynamics in Japanese and Caucasian subjects. Br J Clin Pharmacol. 2006Abstract Full text (in our servers)