Alizapride Hydrochloride
A prokinetic from the benzamide group, a dopamine antagonist and similar to metoclopramide (Humax 2008).
Used IV, IM and orally every 8 to 12 hours for the treatment of nausea and vomiting.
Since the last update we have not found published data on its excretion in breastmilk.
Due to its chemical similarity to metoclopramide, its excretion in breastmilk could be minimal.
Due to its inhibitory effect on dopamine (DrugBank.com), milk production could increase due to an increase in prolactin (Minapharm 2014, Humax 2008).
A product with very few bibliographical references and sold in very few countries.
Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable.
Alternatives
- Metoclopramide (Very Low Risk)
- Domperidone (Very Low Risk)
- Ondansetron (Very Low Risk)
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Writings
- Αλιζαπρίδη (Greek)
- Ализаприда Гидрохлорид (Cyrillic)
- アリザプリド塩酸塩 (Japanese)
- Alizapride Chlorhydrate (French)
- C16 H21 N5 O2, HCl (Molecular formula)
- N-(1-Allyl-2-pyrrolidinylmethyl)-6-methoxy-1H-benzotriazole-5-carboxamide hydrochloride (Chemical name)
- A03FA05 (ATC Code/s)
Drug trade names
References
- Minapharm. Alizapride (Nausilex). Drug Summary. 2014 Full text (in our servers)
- Humax. Alizaprida. Ficha técnica. 2008 Full text (in our servers)
- Houin G, Barre J, Tillement JP. Absolute intramuscular, oral, and rectal bioavailability of alizapride. J Pharm Sci. 1984Abstract