Is Amisulpride compatible with breastfeeding? Do we have alternatives for Amisulpride?

Amisulpride

July 2, 2015 (Low Risk)

It concentrates in the breast milk with an excretion that could be significant. However, side-effects on breastfed infants from treated mothers have not been observed. Probably because a low oral bioavailability, serum levels found in such infants have been also low.

Like other benzamide-based substances, it may increase serum levels of Prolactin and induce galactorrhea,

Until more data on this drug is available, a safer alternative should be chosen mostly during neonatal period and with prematurity.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • Αμισουλπρίδη (Greek)
  • أميسولبريد (Arabic)
  • Амисульприд (Cyrillic)
  • 氨磺必利 (Chinese)
  • アミスルプリド (Japanese)
  • C17 H27 N3 O4 S (Molecular formula)

Drug trade names

References

  1. Uguz F. Breastfed Infants Exposed to Combined Antipsychotics: Two Case Reports. Am J Ther. 2015Abstract
  2. Grover S, Avasthi A. Mood stabilizers in pregnancy and lactation. Indian J Psychiatry. 2015Abstract Full text (link to original source) Full text (in our servers)
  3. Lee BH, Kang SG, Kim TW, Lee HJ, Yoon HK, Park YM. Hyperprolactinemia induced by low-dosage amisulpride in Korean psychiatric patients. Psychiatry Clin Neurosci. 2012Abstract
  4. Teoh S, Ilett KF, Hackett LP, Kohan R. Estimation of rac-amisulpride transfer into milk and of infant dose via milk during its use in a lactating woman with bipolar disorder and schizophrenia. Breastfeed Med. 2011Abstract
  5. Juruena MF, de Sena EP, de Oliveira IR. Safety and tolerability of antipsychotics: focus on amisulpride. Drug Healthc Patient Saf. 2010Abstract Full text (link to original source) Full text (in our servers)
  6. Ilett KF, Watt F, Hackett LP, Kohan R, Teoh S. Assessment of infant dose through milk in a lactating woman taking amisulpride and desvenlafaxine for treatment-resistant depression. Ther Drug Monit. 2010Abstract
  7. Raj R, Sidhu BS. Hyperprolactinaemia with amisulpride. Indian J Psychiatry. 2008Abstract
  8. Paparrigopoulos T, Liappas J, Tzavellas E, Mourikis I, Soldatos C. Amisulpride-induced hyperprolactinemia is reversible following discontinuation. Prog Neuropsychopharmacol Biol Psychiatry. 2007Abstract
  9. Kopecek M, Bares M, Svarc J, Dockery C, Horácek J. Hyperprolactinemia after low dose of amisulpride. Neuro Endocrinol Lett. 2004Abstract
  10. Fric M, Laux G. [Prolactin Levels and Symptoms of Hyperprolactinemia in Patients Treated with Amisulpride, Risperidone, Olanzapine and Quetiapine] Psychiatr Prax. 2003Abstract
  11. Rosenzweig P, Canal M, Patat A, Bergougnan L, Zieleniuk I, Bianchetti G. A review of the pharmacokinetics, tolerability and pharmacodynamics of amisulpride in healthy volunteers. Hum Psychopharmacol. 2002Abstract