Is Amoxapine compatible with breastfeeding? Do we have alternatives for Amoxapine?

Amoxapine

June 30, 2015 (Very Low Risk)

Small amount is excreted into breast milk.

No adverse effect has been observed in infants.

Galactorrhea and oligomenorrhea have been reported in women.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • Αμοξαπίνη (Greek)
  • أموكسابين (Arabic)
  • Амоксапин (Cyrillic)
  • 阿莫沙平 (Chinese)
  • アモキサピン (Japanese)

Drug trade names

References

  1. Sriraman NK, Melvin K, Meltzer-Brody S. ABM Clinical Protocol #18: Use of Antidepressants in Breastfeeding Mothers. Breastfeed Med. 2015Abstract Full text (link to original source) Full text (in our servers)
  2. Davanzo R, Copertino M, De Cunto A, Minen F, Amaddeo A. Antidepressant drugs and breastfeeding: a review of the literature. Breastfeed Med. 2011Abstract
  3. Drugs.com: Amoxapine Data Sheet 2009 Full text (in our servers)
  4. Academy of Breastfeeding Medicine Protocol Committee. ABM clinical protocol #18: use of antidepressants in nursing mothers. Breastfeed Med. 2008Abstract Full text (link to original source) Full text (in our servers)
  5. Rubin ET, Lee A, Ito S. When breastfeeding mothers need CNS-acting drugs. Can J Clin Pharmacol. 2004Abstract
  6. Egberts AC, Meyboom RH, De Koning FH, Bakker A, Leufkens HG. Non-puerperal lactation associated with antidepressant drug use. Br J Clin Pharmacol. 1997Abstract Full text (link to original source) Full text (in our servers)
  7. Koizumi K, Aono T, Tanizawa O. The acute effects of antidepressants, maprotiline and amoxapine on serum prolactin and gonadotropin levels in normal women. Asia Oceania J Obstet Gynaecol. 1986Abstract
  8. Robertson AG, Berry R, Meltzer HY. Prolactin stimulating effects of amoxapine and loxapine in psychiatric patients. Psychopharmacology (Berl). 1982Abstract
  9. Cooper DS, Gelenberg AJ, Wojcik JC, Saxe VC, Ridgway EC, Maloof F. The effect of amoxapine and imipramine on serum prolactin levels. Arch Intern Med. 1981Abstract
  10. Gelenberg AJ. Single case study. Amoxapine, a new antidepressant, appears in human milk. J Nerv Ment Dis. 1979Abstract
  11. Gelenberg AJ, Cooper DS, Doller JC, Maloof F. Galactorrhea and hyperprolactinemia associated with amoxapine therapy. Report of a case. JAMA. 1979Abstract
  12. Jaffe K, Zisook S. Galactorrhea in a patient treated with amoxapine. J Clin Psychiatry. 1978Abstract