Is Anastrozole compatible with breastfeeding? Do we have alternatives for Anastrozole?

Anastrozole

October 12, 2018 (Very High Risk)

Steroidal aromatase inhibitor that impedes long-lasting estrogen synthesis.

On latest update relevant data on breastfeeding was not found.

Excretion into breast milk is very likely.

After a 10 half-lives period (about 20 days) no trace would remain in the milk.

Alternatives

We do not have alternatives for Anastrozole.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • Αναστροζόλη (Greek)
  • أناستروزول (Arabic)
  • Анастрозол (Cyrillic)
  • 阿那罗唑 (Chinese)
  • アナストロゾール (Japanese)
  • C17 H19 N5 (Molecular formula)
  • 2,2′-Dimethyl-2,2′-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]bis(propiononitrile); α,α,α′,α′-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile (Chemical name)
  • L02BG03 (ATC Code/s)

Drug trade names

References

  1. Hale TW, Rowe HE. Medications & Mothers' Milk. A Manual of Lactation Pharmacology. Springer Publishing Company. 2017
  2. Anderson PO. Cancer Chemotherapy. Breastfeed Med. 2016Abstract Full text (link to original source) Full text (in our servers)
  3. AEMPS-Stada. Anastrozol. Ficha técnica. 2016 Full text (in our servers)
  4. Astra-Zeneca. Anastrozole. Data Sheet. 2010 Full text (in our servers)
  5. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, second edition. London. 2007