Is Arginine compatible with breastfeeding? Do we have alternatives for Arginine?

Arginine

May 13, 2018 (Very Low Risk)

An amino acid component of proteins.
Found in meat, fish, dairy products, nuts and seeds (AESAN 2012). It stimulates the production of nitric oxide (vasodilatory) and the release of insulin and growth hormone.

It is indicated in states of deficiencies due to states of high catabolism or a very protein deficient diet. Most of its attributed therapeutic properties are not well-proven (MedlinePlus 2012, AESAN 2012). It is used in diagnostic tests for growth hormone (Biomed 2009).

It is found naturally in breastmilk at a higher concentration in colostrum than in mature milk (Lawrence 2016 p.766, Bjelaković 2010).

Since the last update we have not found published data in relation to breastfeeding.

Although an excess of amino acids or proteins in the diet can increase plasma levels, the concentration of proteins and other components of the milk is regulated in the epithelial mammary cell and is very independent of the plasma concentrations.

It has been used to prevent necrotizing enterocolitis in premature infants (MedlinePlus2012, Lee 2011, Thompson 2008).

It has a high safety profile, with no adverse effects observed at the recommended doses. A maximum daily intake of up to 3g (AESAN 2012) is advised.

Its moderate and non-abusive consumption is probably harmless during breastfeeding. 

Alternatives

We do not have alternatives for Arginine since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Arginine Aspartate
  • Arginine Glutamate
  • Arginine Hydrochloride
  • L-Arginine

Writings

  • Αργινίνη (Greek)
  • أرجينين (Arabic)
  • Аргинин (Cyrillic)
  • 精氨酸 (Chinese)
  • L-アルギニン (Japanese)
  • C6 H14 N4 O2 (Molecular formula)
  • l-2-Amino-5-guanidinovaleric acid (Chemical name)
  • A05BA01 y 07 (ATC Code/s)
  • A16AA (ATC Code/s)
  • B05XB01 (ATC Code/s)

References

  1. AEMPS. Arginina (Potenciator). Ficha técnica. 2014 Full text (in our servers)
  2. AESAN. Informe del Comité Científico de la Agencia Española de Seguridad Alimentaria y Nutrición (AESAN) sobre condiciones de uso de determinadas sustancias distintas de vitaminas, minerales y plantas para ser empleadas en complementos alimenticios - 1. Revista del comité científico nº 17. 2012 Full text (in our servers)
  3. MedlinePLus Arginine MedlinePlus Supplements. 2012 Full text (link to original source) Full text (in our servers)
  4. MedlinePlus. Arginina MedlinePlus Suplementos. 2012 Full text (link to original source) Full text (in our servers)
  5. Lee JH. An update on necrotizing enterocolitis: pathogenesis and preventive strategies. Korean J Pediatr. 2011Abstract Full text (in our servers)
  6. Bjelaković L, Kocić G, Cvetković T, Stojanović D, Najmen S, Jevtovic T, Bjelaković B, Pop-Trajković Z, Bjelaković G. Arginase activity in human milk during the first month of lactation. J Basic Clin Physiol Pharmacol. 2010Abstract
  7. Biomed Ltd. Arginine Data Sheet 2009 Full text (in our servers)
  8. Thompson AM, Bizzarro MJ. Necrotizing enterocolitis in newborns: pathogenesis, prevention and management. Drugs. 2008Abstract
  9. van Haeften TW, Konings CH. Arginine pharmacokinetics in humans assessed with an enzymatic assay adapted to a centrifugal analyzer. Clin Chem. 1989Abstract Full text (in our servers)