Is Atracurium compatible with breastfeeding? Do we have alternatives for Atracurium?

Atracurium

January 6, 2015 (Very Low Risk)

It is a non-depolarizing muscle relaxant drug with a peripheral action that is used as premedication for endotracheal intubation, general anesthesia and mechanical ventilation.

At latest update, no relevant published data concerning excretion into breast milk were found.

Because a relatively high molecular-weight and a high protein-binding capacity, excretion into breast milk is thought to be low.

In addition, it has a low oral bioavailability which means that absorption from the breast milk ingested may be low.

Atracurium should not prevent a mother from breast feeding her baby shortly after recovering from an anesthesia if she is in good condition.

Alternatives

We do not have alternatives for Atracurium since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Cisatracurium Besilate
  • أتراكوريوم
  • Ατρακούριο
  • Σισατρακούριο
  • Атракурия
  • 苯磺阿曲库铵
  • ベシル酸アトラクリウム

References

  1. Dalal PG, Bosak J, Berlin C. Safety of the breast-feeding infant after maternal anesthesia. Paediatr Anaesth. 2014Abstract
  2. Atracurio. Ficha técnica. 2011 Full text (in our servers)
  3. Ferriols Lisart R,Ferriols Lisart F. Farmacología clínica y usos terapéuticos del Mivacurio. Farm Hosp. 1997 Full text (in our servers)
  4. Atracurium. Drug Summary. 1996 Full text (in our servers)
  5. Spigset O. Anaesthetic agents and excretion in breast milk. Acta Anaesthesiol Scand. 1994Abstract
  6. Colin JN, Singlas E. [Metabolism and pharmacokinetics of atracurium]. Ann Fr Anesth Reanim. 1985Abstract
  7. Ward S, Neill EA, Weatherley BC, Corall IM. Pharmacokinetics of atracurium besylate in healthy patients (after a single i.v. bolus dose). Br J Anaesth. 1983Abstract