Baclofen
Centrally acting Myorelaxant.
Indicated for spastic disorders associated with degenerative illnesses and cerebral palsy.
Excreted into breast milk in non-significant clinical amount with no harm effects reported among breastfed infants from treated mothers.
When administered in pregnancy, symptoms of Abstinence Syndrome may appear,
Intrathecal administration shows small serum levels by which it is assumed that the amount present in breast milk must be even lower.
Oral administration has been authorized since neonatal age in the UK and one year of life in Spain.
Follow-up of milk production is recommended since a theoretically based inhibition of Prolactin may occur.
American Academy of Pediatrics: medication usually compatible with breastfeeding.
Alternatives
We do not have alternatives for Baclofen since it is relatively safe.
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Writings
- باكلوفان (Arabic)
- Баклофен (Cyrillic)
- 巴氯芬 (Chinese)
- バクロフェン (Japanese)
Drug trade names
- Atrofen™
- Baclan™
- Baclohexal™
- Baclon™
- Baclopar™
- Baclosal™
- Baclosan (Баклосан)™
- Bacmax™
- Cetril™
- Chinofen™
- Clofen™
- Colmifen™
- Fenisal™
- Gablofen™
- Glasbor™
- Jofen™
- Liobac™
- Liofen™
- Lioresal (力奥来素)™
- Lioresal™
- Lioresyl™
- Liotec™
- Lyflex™
- Miorel™ (Greece)
- Nu-Baclo™
- Onelaxant-R™
- Pacifen™
- Parafon DSC™
- Spinax (郝智)™
- Stelax™
- Vioridon™
- Zufen (枢芬)™
- БАКЛОФЕН
References
- Almas S, Vance J, Baker T, Hale T. Management of Multiple Sclerosis in the Breastfeeding Mother. Mult Scler Int. 2016Abstract Full text (link to original source) Full text (in our servers)
- AEMPS Baclofeno intratecal Ficha técnica 2012 Full text (link to original source) Full text (in our servers)
- IQB Baclofeno oral Ficha técnica 2008 Full text (link to original source) Full text (in our servers)
- Omari TI, Benninga MA, Sansom L, Butler RN, Dent J, Davidson GP. Effect of baclofen on esophagogastric motility and gastroesophageal reflux in children with gastroesophageal reflux disease: a randomized controlled trial. J Pediatr. 2006Abstract
- Moran LR, Almeida PG, Worden S, Huttner KM. Intrauterine baclofen exposure: a multidisciplinary approach. Pediatrics. 2004Abstract Full text (link to original source) Full text (in our servers)
- AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001Abstract Full text (link to original source) Full text (in our servers)
- Morosini PP, Carletti P, Sarzani R, Ferretti GF, Marchesi GF, Nardi B. [Prolactin after baclofen in healthy subjects and prolactinoma patients]. Boll Soc Ital Biol Sper. 1985Abstract
- Eriksson G, Swahn CG. Concentrations of baclofen in serum and breast milk from a lactating woman. Scand J Clin Lab Invest. 1981Abstract
- Potkin SG, Gillin JC, Rogol A, Nasrallah HA, Wyatt RJ. Baclofen: lack of effect on human plasma prolactin. Commun Psychopharmacol. 1978Abstract