Is Benznidazole compatible with breastfeeding? Do we have alternatives for Benznidazole?

Benznidazole

July 11, 2017 (Very Low Risk)

Antiprotozoan drug used for the treatment of American Trypanosomiasis (Trypanosoma cruzi) or Chagas Disease (see specific info).

It is excreted into breast milk in small amounts and there have not been observed problems in infants from treated mothers (Garcia-Bournissen 2015, Vela-Bahena 2015).

Benznidazole has been very well tolerated when administered directly to infants and newborns (Altcheh 2011, Chippaux 2013).


See below the information of this related product:

Alternatives

We do not have alternatives for Benznidazole since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • بانزنيدازول (Arabic)
  • Бензнидазол (Cyrillic)
  • 苄硝唑 (Chinese)
  • ベンズニダゾール (Japanese)
  • C12H12N4O3 (Molecular formula)

Drug trade names

References

  1. García-Bournissen F, Moroni S, Marson ME, Moscatelli G, Mastrantonio G, Bisio M, Cornou L, Ballering G, Altcheh J. Limited infant exposure to benznidazole through breast milk during maternal treatment for Chagas disease. Arch Dis Child. 2015Abstract Full text (link to original source) Full text (in our servers)
  2. Vela-Bahena LE, Vergara R, Vite L, Ramos C. Tratamiento posparto en una paciente con enfermedad de Chagas, sin interrupción de la lactancia. [Postpartum treatment without interrupting breastfeeding in a patient with Chagas disease]. Ginecol Obstet Mex. 2015Abstract Full text (link to original source) Full text (in our servers)
  3. García-Bournissen F, Moroni S, Marson ME, Moscatelli G, Mastrantonio G, Bisio M, Cornou L, Ballering G, Altcheh J. Limited infant exposure to benznidazole through breast milk during maternal treatment for Chagas disease. Arch Dis Child. 2014Abstract
  4. Chippaux JP, Salas-Clavijo AN, Postigo JR, Schneider D, Santalla JA, Brutus L. Evaluation of compliance to congenital Chagas disease treatment: results of a randomised trial in Bolivia. Trans R Soc Trop Med Hyg. 2013Abstract Full text (in our servers)
  5. Marson ME, Padró JM, Reta MR, Altcheh J, García-Bournissen F, Mastrantonio G. A simple and efficient HPLC method for benznidazole dosage in human breast milk. Ther Drug Monit. 2013Abstract
  6. Altcheh J, Moscatelli G, Moroni S, Garcia-Bournissen F, Freilij H. Adverse events after the use of benznidazole in infants and children with Chagas disease. Pediatrics. 2011Abstract
  7. Pérez JL, Carranza C, Mateos F. Antiparasitarios. Revisión de los fármacos útiles en el tratamiento de parasitosis clásicas y emergentes. \ [Antiparasitic drugs. Review of the useful drugs in the treatment of classic and emergent parasitic diseases]. Rev Esp Quimioter. 2009Abstract Full text (link to original source) Full text (in our servers)
  8. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  9. Shikanai-Yasuda MA, Lopes MH, Tolezano JE, Umezawa E, Amato Neto V, Barreto AC, Higaki Y, Moreira AA, Funayama G, Barone AA, et al. [Acute Chagas' disease: transmission routes, clinical aspects and response to specific therapy in diagnosed cases in an urban center]. Rev Inst Med Trop Sao Paulo. 1990Abstract Full text (in our servers)
  10. Raaflaub J, Ziegler WH. Single-dose pharmacokinetics of the trypanosomicide benznidazole in man. Arzneimittelforschung. 1979Abstract