Is Benzydamine Hydrochloride compatible with breastfeeding? Do we have alternatives for Benzydamine Hydrochloride?

Benzydamine Hydrochloride

March 29, 2016 (Very Low Risk)

Nonsteroidal antiinflammatory agent that is locally used on skin and in solution for oral application or vaginal douche.

At latest update no published data on excretion into breast milk were found.

Because the small dose used and low absorption of most topical dermatological preparations with limited absorption to plasma, it is unlikely the passage of significant amounts to breast milk. This is true whenever there is not abuse of it since cases of renal impairment after prolonged and excessive administration have been reported.

If used, do not apply on the chest, large areas and for prolonged periods of time to prevent a systemic absorption.

Alternatives

We do not have alternatives for Benzydamine Hydrochloride since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • Βενζυδαμίνη υδροχλωρική (Greek)
  • Бензидамина Гидрохлорид (Cyrillic)
  • 塩酸ベンジダミン (Japanese)
  • C19 H23 N3O, HCl (Molecular formula)

References

  1. MHRA. Benzydamine. Drug Summary. 2015 Full text (in our servers)
  2. AEMPS. Beincidamina. Ficha técnica. 1999 Full text (in our servers)
  3. O'Callaghan CA, Andrews PA, Ogg CS. Renal disease and use of topical non-steroidal anti-inflammatory drugs. BMJ. 1994Abstract Full text (link to original source) Full text (in our servers)
  4. Baldock GA, Brodie RR, Chasseaud LF, Taylor T, Walmsley LM, Catanese B. Pharmacokinetics of benzydamine after intravenous, oral, and topical doses to human subjects. Biopharm Drug Dispos. 1991Abstract
  5. Chasseaud LF, Catanese B. Pharmacokinetics of benzydamine. Int J Tissue React. 1985Abstract
  6. Catanese B, Facchini V, Barillari G, Putzolu S. Serum levels of benzydamine following the topical use of this drug in gynecology. Clin Exp Obstet Gynecol. 1980Abstract