Is Bifonazole compatible with breastfeeding? Do we have alternatives for Bifonazole?


October 20, 2016 (Very Low Risk)

Topical antifungal medication which is indicated for the treatment of mycosis of skin and nails.

At latest update relevant published data were not found on excretion into breast milk.

A negligible systemic absorption through the skin - less than 1% on intact skin and up to 4% on inflamed skin (Fromtling 1988) - makes very unlikely that significant amounts would be excreted into breast milk.

Do not apply on the breast to prevent ingestion by the infant; otherwise, do it just after a meal and clean the nipple thoroughly with water before the next feed.

Local application on the nipple of creams, gels and other products containing paraffin (mineral oil) should better be avoid to keep the infant off from absorption (Noti 2003, Concin 2008).


We do not have alternatives for Bifonazole since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.


  • Bifonazole Cream
  • Biphenyl-4-Imidazole
  • Ovules


  • Βιφοναζόλη (Greek)
  • بيفونازول (Arabic)
  • Бифоназол (Cyrillic)
  • 联苯苄唑 (Chinese)
  • ビホナゾール (Japanese)
  • C22H18N2 (Molecular formula)
  • Bay-h-4502 (Experimental code/s)


  1. AEMPS. Bifonazol. Ficha técnica. 2016 Full text (in our servers)
  2. Bayer. Bifonazole. Drug Summary. 2009 Full text (in our servers)
  3. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003Abstract
  4. Fromtling RA. Overview of medically important antifungal azole derivatives. Clin Microbiol Rev. 1988Abstract Full text (link to original source) Full text (in our servers)
  5. Lücker PW, Beubler E, Kukovetz WR, Ritter W. Retention time and concentration in human skin of bifonazole and clotrimazole. Dermatologica. 1984Abstract