Bismuth salts
Bismuth salts are used alone or together with other components in preparations against gastritis and diarrhea.
Bismuth salicylate contains about 60% bismuth and 40% salicylate.
At latest update no published data on excretion into breast milk were found.
Bismuth is not absorbed into the systemic circulation of the mother.
There may be a risk of absorption of salicylate in the case of bismuth salicylate, although in small quantity (<1% of the maternal dose), but no cases of Reye's syndrome have been reported after taking bismuth salicylate or other non-acetylated salicylate compounds.
Due to the otherwise minimum risk of Reye's syndrome and the indiscriminate use of bismuth subsalicylate for treatment of gastroenteritis cannot be justifiable since most of gastroenteritis do not require medication instead a simply adequate hydration, a safer alternative should be desirable while breastfeeding, like the other salts of bismuth (citrate, etc).
Alternatives
- Omeprazole (Very Low Risk)
- Loperamide Hydrochloride (Very Low Risk)
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Synonyms
- Bismuth Aluminate
- Bismuth Citrate
- Bismuth Salicylate
- Bismuth Subcarbonate
- Bismuth Subcitrate Potassium
- Bismuth Subnitrate
- Bismuth Sub/Oxysalicylate
- Tripotassium Dicitratobismuthate
Writings
- Βισμούθιο σαλικυλικό (Greek)
- Салицилат Висмута (Cyrillic)
- 次サリチル酸ビスマス (Japanese)
- C7H5BiO4 (Molecular formula)
Drug trade names
References
- Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010Abstract Full text (link to original source) Full text (in our servers)
- Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006Abstract Full text (link to original source) Full text (in our servers)
- Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000Abstract
- Anderson PO. Drug use during breast-feeding. Clin Pharm. 1991Abstract
- Lewis JH, Weingold AB. The use of gastrointestinal drugs during pregnancy and lactation. Am J Gastroenterol. 1985Abstract
- Findlay JW, DeAngelis RL, Kearney MF, Welch RM, Findlay JM. Analgesic drugs in breast milk and plasma. Clin Pharmacol Ther. 1981Abstract