Is Brivudine compatible with breastfeeding? Do we have alternatives for Brivudine?

Brivudine

March 22, 2015 (Low Risk)

Medication used for treatment of Herpes zoster infection.

At latest update, relevant published data on excretion into breast milk were not found.

Because a high distribution volume (DV) and high protein-binding capacity, excretion into breast milk in significant amount is very unlikely.

A low oral bioavailability impairs the pass of it from the mother's milk to the infant's plasma, except in prematures or in the early neonatal period, when a higher intestinal absorption may occur.

Until more data on this medication is available, safer alternative drugs are preferred, especially in such critical age periods.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • ブリブジン
  • Bromovinyldeoxyuridine
  • بريفودين
  • Бривудин
  • 溴夫定

Drug trade names

References

  1. McDonald EM, de Kock J, Ram FS. Antivirals for management of herpes zoster including ophthalmicus: a systematic review of high-quality randomized controlled trials. Antivir Ther. 2012Abstract
  2. AEMPS. Brivudina. Ficha técnica. 2010 Full text (in our servers)
  3. Wassilew S; Collaborative Brivudin PHN Study Group. Brivudin compared with famciclovir in the treatment of herpes zoster: effects in acute disease and chronic pain in immunocompetent patients. A randomized, double-blind, multinational study. J Eur Acad Dermatol Venereol. 2005Abstract
  4. Keam SJ, Chapman TM, Figgitt DP. Brivudin (bromovinyl deoxyuridine). Drugs. 2004Abstract
  5. Rabasseda X. Brivudine: a herpes virostatic with rapid antiviral activity and once-daily dosing. Drugs Today (Barc). 2003Abstract