Is Buprenorphine compatible with breastfeeding? Do we have alternatives for Buprenorphine?

Buprenorphine

October 28, 2014 (Very Low Risk)

It is a semi-synthetic opioid which is used to replace Methadone in the treatment of opioid addiction. Mothers on Buprenorphine showed a shorter mean hospital stay than those who were treated with Methadone.

The amount of dose reaching the infant is minimal and has no untoward side effects. It has been noticed a mild and transient abstinence syndrome after birth when sudden withdrawn occurred.

Addiction to narcotic drugs and the use of substitutive treatments lowers the breastfeeding rate and duration of nursing.

Alternatives

We do not have alternatives for Buprenorphine since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Drug trade names

References

  1. Lefevere J, Allegaert K. Question: is breastfeeding useful in the management of neonatal abstinence syndrome? Arch Dis Child. 2015Abstract
  2. ABM Protocolo clínico de la ABM n.º 21: Pautas para la lactancia y el consumo de sustancias o trastorno por consumo de sustancias, revisado en 2015. Breastfeed Med. 2015 Full text (link to original source) Full text (in our servers)
  3. Reece-Stremtan S, Marinelli KA. ABM Clinical Protocol #21: Guidelines for Breastfeeding and Substance Use or Substance Use Disorder, Revised 2015. Breastfeed Med. 2015Abstract Full text (link to original source) Full text (in our servers)
  4. Kocherlakota P. Neonatal abstinence syndrome. Pediatrics. 2014Abstract Full text (link to original source) Full text (in our servers)
  5. Sutter MB, Leeman L, Hsi A. Neonatal opioid withdrawal syndrome. Obstet Gynecol Clin North Am. 2014Abstract
  6. Bagley SM, Wachman EM, Holland E, Brogly SB. Review of the assessment and management of neonatal abstinence syndrome. Addict Sci Clin Pract. 2014Abstract Full text (link to original source) Full text (in our servers)
  7. Logan BA, Brown MS, Hayes MJ. Neonatal abstinence syndrome: treatment and pediatric outcomes. Clin Obstet Gynecol. 2013Abstract Full text (link to original source) Full text (in our servers)
  8. Welle-Strand GK, Skurtveit S, Jansson LM, Bakstad B, Bjarkø L, Ravndal E. Breastfeeding reduces the need for withdrawal treatment in opioid-exposed infants. Acta Paediatr. 2013Abstract
  9. D'Apolito K. Breastfeeding and substance abuse. Clin Obstet Gynecol. 2013Abstract
  10. Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013Abstract Full text (link to original source) Full text (in our servers)
  11. Pritham UA, Paul JA, Hayes MJ. Opioid dependency in pregnancy and length of stay for neonatal abstinence syndrome. J Obstet Gynecol Neonatal Nurs. 2012Abstract Full text (link to original source) Full text (in our servers)
  12. Yep T, Eyal S, Easterling TR, Shen DD, Kelly EJ, Hankins GDV, Caritis S, Risler L, Hebert MF. The pharmacokinetics of metoprolol during pregnancy. American College of Clinical Pharmacy 2011 Annual Meeting. Abstract 471. Pharmacotherapy. 2011;31:439e. 2011 Full text (link to original source) Full text (in our servers)
  13. Hirose M, Hosokawa T, Tanaka Y. Extradural buprenorphine suppresses breast feeding after caesarean section. Br J Anaesth. 1997Abstract Full text (link to original source) Full text (in our servers)