Caffeine
Trimethylxanthine component which is present in many compounds like decongestant or pain relief drugs (50 to 100 mg per unit) .
It is also present in many infusion beverages (coffee, tea, mate, guarana) and other drinks with allegedly energizing properties. See also Coffee, Caffeine (beverages).
At a dose higher than 300 mg a-day may induce nervousness and irritability in the infant. Intravenous high doses used to treat post-epidural anesthesia headache within 2-3 days after delivery, before mature breast milk comes, are compatible with breastfeeding.
High doses used Intravenously to treat headache related to epidural should be regarded as compatible with breastfeeding only in the 2-3 days before milk comes in.
Elimination period may last from few hours in adults, to 3-4 days in the newborn infant.
American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.
See below the information of this related product:
- Coffee (Low Risk probable)
Alternatives
We do not have alternatives for Caffeine.
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Synonyms
- Guaranine
- Methyltheobromine
- Theine
Writings
- Καφεΐνη (Greek)
- Кофеин (Cyrillic)
- カフェイン (Japanese)
- C8 H10 N4 O2 (Molecular formula)
- 1,3,7-Trimethylpurine-2,6(3H,1H)-dione; 1,3,7-Trimethylxanthine; 7-Methyltheophylline (Chemical name)
- N06BC01 (ATC Code/s)
Drug trade names
- Actron Compuesto™ (Spain)
- Actron Plus™ (Mexico)
- Actron™ (France)
- Algofetin (Альгофетин)™
- Analgilasa™
- Antigrippine™ (Netherlands)
- Antigrippine™ (Portugal)
- Cafcit™
- Cafergot™
- Caffedrine™
- Cafnea™
- Cefecon N (Цефекон Н)™
- Cinfamar Cafeina™
- Coffekapton™
- Desenfriol C™
- Desenfriol™
- Dolanet™
- Dolex Forte™ (Colombia)
- Dristan Compuesto™
- Dristan™ (India)
- Durvitan™
- Enerjets™
- Facitor™
- Fiorinal™ (Canada, United States of America)
- Flodigrip C™
- Flodigrip Descongestivo™
- Flodigrip-NF™
- Frenadol Complex™
- Gripanil C™
- Hemicraneal™
- Jaquedryl™
- Kafesit™
- Kang Yu Deng Tong (康裕登通)™
- Keep Alert™
- Kinedryl™
- Kofan (Кофан)™
- Lipofeine™
- Lucidex™
- Mejoral Cafeina™
- Midol Menstrual Complete™
- Neo Optalidon™ (Italy)
- No Doz™
- NoDoz™
- Novalgin (Новалгин)™
- Optalidon N™ (Germany)
- Optalidon™
- Optalidon™ (Belgium, Brazil, Portugal, Spain)
- Optalidon™ (Italy)
- Panadol Extra™
- Panadol Plus™
- Panadol Ultra™
- Pep-Back™
- Percutafeine™
- Peyona™
- Pro-Plus™
- Sanalgin N™
- Saridon N™ (Portugal)
- Saridon™
- Sinutab™ (Brazil)
- Stay Alert™
- Tonopan™
- Tylenol n1-n2-n3™
- Vasobral (Вазобрал)™
- Vivarin™
- Wake Ups™
- Zaat™
- КОФЕЇН
- КОФЕЇН БЕЗВОДНИЙ
- ПЕЙОНА
References
- Bordini CA, Roesler C, Carvalho Dde S, Macedo DD, Piovesan É, Melhado EM, Dach F, Kowacs F, Silva Júnior HM, Souza JA, Maciel JA Jr, Carvalho JJ, Speciali JG, Barea LM, Queiroz LP, Ciciarelli MC, Valença MM, Lima MM, Vincent MB. Recommendations for the treatment of migraine attacks - a Brazilian consensus. Arq Neuropsiquiatr. 2016Abstract Full text (link to original source) Full text (in our servers)
- Yurcheshen M, Seehuus M, Pigeon W. Updates on Nutraceutical Sleep Therapeutics and Investigational Research. Evid Based Complement Alternat Med. 2015Abstract Full text (link to original source) Full text (in our servers)
- Davanzo R, Bua J, Paloni G, Facchina G. Breastfeeding and migraine drugs. Eur J Clin Pharmacol. 2014Abstract
- Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. 2013Abstract
- Escuder-Vieco D, Garcia-Algar O, Pichini S, Pacifici R, García-Lara NR, Pallás-Alonso CR. Validation of a Screening Questionnaire for a Human Milk Bank to Determine the Presence of Illegal Drugs, Nicotine, and Caffeine. J Pediatr. 2013Abstract
- McGuinness N, Cording V. Raynaud's phenomenon of the nipple associated with labetalol use. J Hum Lact. 2013Abstract Full text (link to original source) Full text (in our servers)
- Pituch A, Hamułka J, Wawrzyniak A, Zdanowski K. [Assessment of stimulant use especially caffeine intake in selected group of the breastfeeding women]. Rocz Panstw Zakl Hig. 2012Abstract
- Santos IS, Matijasevich A, Domingues MR. Maternal caffeine consumption and infant nighttime waking: prospective cohort study. Pediatrics. 2012Abstract Full text (link to original source) Full text (in our servers)
- Martín I, López-Vílchez MA, Mur A, García-Algar O, Rossi S, Marchei E, Pichini S. Neonatal withdrawal syndrome after chronic maternal drinking of mate. Ther Drug Monit. 2007Abstract
- McNamara PJ, Abbassi M. Neonatal exposure to drugs in breast milk. Pharm Res. 2004Abstract
- AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001Abstract Full text (link to original source) Full text (in our servers)
- Mitchell JL. Use of cough and cold preparations during breastfeeding. J Hum Lact. 1999Abstract
- Liston J. Breastfeeding and the use of recreational drugs--alcohol, caffeine, nicotine and marijuana. Breastfeed Rev. 1998Abstract
- Barone JJ, Roberts HR. Caffeine consumption. Food Chem Toxicol. 1996Abstract
- Oo CY, Burgio DE, Kuhn RC, Desai N, McNamara PJ. Pharmacokinetics of caffeine and its demethylated metabolites in lactation: predictions of milk to serum concentration ratios. Pharm Res. 1995Abstract
- Blanchard J, Weber CW, Shearer LE. Methylxanthine levels in breast milk of lactating women of different ethnic and socioeconomic classes. Biopharm Drug Dispos. 1992Abstract
- Fulton B. The galactopharmacopedia. Recreational drug use in the breastfeeding mother. Part 2: Licit drugs. J Hum Lact. 1990Abstract
- Muñoz LM, Lönnerdal B, Keen CL, Dewey KG. Coffee consumption as a factor in iron deficiency anemia among pregnant women and their infants in Costa Rica. Am J Clin Nutr. 1988Abstract Full text (link to original source) Full text (in our servers)
- Stavchansky S, Combs A, Sagraves R, Delgado M, Joshi A. Pharmacokinetics of caffeine in breast milk and plasma after single oral administration of caffeine to lactating mothers. Biopharm Drug Dispos. 1988Abstract
- Ryu JE. Effect of maternal caffeine consumption on heart rate and sleep time of breast-fed infants. Dev Pharmacol Ther. 1985Abstract
- Bucher HU, Gautschi K. [Detection of caffeine, theophylline and theobromine in the umbilical cord blood and breast milk]. Helv Paediatr Acta. 1985Abstract
- Ryu JE. Caffeine in human milk and in serum of breast-fed infants. Dev Pharmacol Ther. 1985Abstract
- Berlin CM Jr, Denson HM, Daniel CH, Ward RM. Disposition of dietary caffeine in milk, saliva, and plasma of lactating women. Pediatrics. 1984Abstract
- Hildebrandt R, Gundert-Remy U. Lack of pharmacological active saliva levels of caffeine in breast-fed infants. Pediatr Pharmacol (New York). 1983Abstract
- Bailey DN, Weibert RT, Naylor AJ, Shaw RF. A study of salicylate and caffeine excretion in the breast milk of two nursing mothers. J Anal Toxicol. 1982Abstract
- Findlay JW, DeAngelis RL, Kearney MF, Welch RM, Findlay JM. Analgesic drugs in breast milk and plasma. Clin Pharmacol Ther. 1981Abstract
- Tyrala EE, Dodson WE. Caffeine secretion into breast milk. Arch Dis Child. 1979Abstract Full text (link to original source) Full text (in our servers)
- Rivera-calimlim L. Drugs in breast milk. Drug Ther (NY). 1977Abstract