Is Carbimazole compatible with breastfeeding? Do we have alternatives for Carbimazole?

Carbimazole

July 11, 2017 (Very Low Risk)

Pro-drug which is metabolized to methimazole that is equivalent to 60% of drug.

Excretion into breast milk is insignificant (Low 1979, Johansen 1972, Rylance 1987).
No adverse effects reported in breastfed infants (Rylance 1987).
Plasma levels in those infants were shown to be very low (Rylance 1987).

Daily dose up to 30 mg has shown to be safe for the infant (Lamberg 1984, Verd 1998, Bartalena 2005) at both short term (hormone serum level) and long term (psychomotor development).follow-up.

The American Academy of Pediatrics rates us as compatible with breastfeeding


See below the information of this related product:

Alternatives

We do not have alternatives for Carbimazole since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Carbimazol

Writings

  • Καρβιμαζόλη (Greek)
  • كاربيمازول (Arabic)
  • Карбимазол (Cyrillic)
  • 卡比马唑 (Chinese)
  • カルビマゾール (Japanese)
  • C7H10N2O2S (Molecular formula)

Drug trade names

References

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  2. Fumarola A, Di Fiore A, Dainelli M, Grani G, Carbotta G, Calvanese A. Therapy of hyperthyroidism in pregnancy and breastfeeding. Obstet Gynecol Surv. 2011Abstract
  3. Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, Nixon A, Pearce EN, Soldin OP, Sullivan S, Wiersinga W; American Thyroid Association Taskforce on Thyroid Disease During Pregnancy and Postpartum.. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011Abstract Full text (link to original source) Full text (in our servers)
  4. Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, Nixon A, Pearce EN, Soldin OP, Sullivan S, Wiersinga W; American Thyroid Association Taskforce on Thyroid Disease During Pregnancy and Postpartum. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011Abstract
  5. Karras S, Tzotzas T, Kaltsas T, Krassas GE. Pharmacological treatment of hyperthyroidism during lactation: review of the literature and novel data. Pediatr Endocrinol Rev. 2010Abstract
  6. Inoue M, Arata N, Koren G, Ito S. Hyperthyroidism during pregnancy. Can Fam Physician. 2009Abstract Full text (link to original source) Full text (in our servers)
  7. Glatstein MM, Garcia-Bournissen F, Giglio N, Finkelstein Y, Koren G. Pharmacologic treatment of hyperthyroidism during lactation. Can Fam Physician. 2009Abstract Full text (link to original source) Full text (in our servers)
  8. Karras S, Tzotzas T, Krassas GE. Antithyroid drugs used in the treatment of hyperthyroidism during breast feeding. An update and new perspectives. Hormones (Athens). 2009Abstract Full text (link to original source) Full text (in our servers)
  9. Azizi F. Treatment of post-partum thyrotoxicosis. J Endocrinol Invest. 2006Abstract
  10. Törnhage CJ, Grankvist K. Acquired neonatal thyroid disease due to TSH receptor antibodies in breast milk. J Pediatr Endocrinol Metab. 2006Abstract
  11. Koren G, Soldin O. Therapeutic drug monitoring of antithyroid drugs in pregnancy: the knowledge gaps. Ther Drug Monit. 2006Abstract Full text (link to original source) Full text (in our servers)
  12. Bartalena L, Tanda ML, Bogazzi F, Piantanida E, Lai A, Martino E. An update on the pharmacological management of hyperthyroidism due to Graves' disease. Expert Opin Pharmacother. 2005Abstract Full text (link to original source) Full text (in our servers)
  13. Azizi F. Thyroid function in breast-fed infants is not affected by methimazole-induced maternal hypothyroidism: results of a retrospective study. J Endocrinol Invest. 2003Abstract
  14. Azizi F, Bahrainian M, Khamseh ME, Khoshniat M. Intellectual development and thyroid function in children who were breast-fed by thyrotoxic mothers taking methimazole. J Pediatr Endocrinol Metab. 2003Abstract
  15. Azizi F, Hedayati M. Thyroid function in breast-fed infants whose mothers take high doses of methimazole. J Endocrinol Invest. 2002Abstract
  16. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001Abstract Full text (link to original source) Full text (in our servers)
  17. Azizi F, Khoshniat M, Bahrainian M, Hedayati M. Thyroid function and intellectual development of infants nursed by mothers taking methimazole. J Clin Endocrinol Metab. 2000Abstract Full text (link to original source) Full text (in our servers)
  18. Verd S, Cardo E. Well-being of a baby breast fed by her mother on carbimazol treatment. J Hum Lact. 1998Abstract
  19. Azizi F. Effect of methimazole treatment of maternal thyrotoxicosis on thyroid function in breast-feeding infants. J Pediatr. 1996Abstract
  20. Cooper DS. Antithyroid drugs: to breast-feed or not to breast-feed. Am J Obstet Gynecol. 1987Abstract
  21. Rylance GW, Woods CG, Donnelly MC, Oliver JS, Alexander WD. Carbimazole and breastfeeding. Lancet. 1987Abstract
  22. Lamberg BA, Ikonen E, Osterlund K, Teramo K, Pekonen F, Peltola J, Välimäki M. Antithyroid treatment of maternal hyperthyroidism during lactation. Clin Endocrinol (Oxf). 1984Abstract
  23. Cooper DS, Bode HH, Nath B, Saxe V, Maloof F, Ridgway EC. Methimazole pharmacology in man: studies using a newly developed radioimmunoassay for methimazole. J Clin Endocrinol Metab. 1984Abstract
  24. Johansen K, Andersen AN, Kampmann JP, Mølholm Hansen JM, Mortensen HB. Excretion of methimazole in human milk. Eur J Clin Pharmacol. 1982Abstract
  25. Kampmann JP, Hansen JM. Clinical pharmacokinetics of antithyroid drugs. Clin Pharmacokinet. 1981Abstract
  26. Tegler L, Lindström B. Antithyroid drugs in milk. Lancet. 1980Abstract
  27. Low LC, Lang J, Alexander WD. Excretion of carbimazole and propylthiouracil in breast milk. Lancet. 1979Abstract