Is Carvedilol compatible with breastfeeding? Do we have alternatives for Carvedilol?

Carvedilol

May 21, 2017 (Low Risk)

Since the last update we have not found published data on its excretion in breast milk.

Its high percentage of plasma protein binding makes excretion in significant amounts very unlikely (Riant 1986).

Other adrenergic beta-blockers of the same family and similar chemical structure are compatible with breastfeeding (see specific information for Labetalol or Propranolol).

Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • كارفيديلول (Arabic)
  • Карведилол (Cyrillic)
  • 卡维地洛 (Chinese)
  • カルベジロール (Japanese)
  • C24H26N2O4 (Molecular formula)

Drug trade names

References

  1. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016Abstract Full text (link to original source) Full text (in our servers)
  2. Tamargo Menéndez J, Delpón Mosquera E. Farmacología de los bloqueantes de los receptores β-adrenérgicos. Curso βeta 2011 de Actualización en Betabloqueantes. 2011 Full text (in our servers)
  3. Shannon ME, Malecha SE, Cha AJ. Beta blockers and lactation: an update. J Hum Lact. 2000Abstract
  4. Riant P, Urien S, Albengres E, Duche JC, Tillement JP. High plasma protein binding as a parameter in the selection of betablockers for lactating women. Biochem Pharmacol. 1986Abstract