Cefdinir
Third-generation cephalosporin for oral administration.
At latest update no published data on excretion into breast milk were found. According to the manufacturer it is not excreted into breast milk (Abbott 2007).
Most cephalosporins are excreted into milk in insignificant amounts from a therapeutic point of view without reported complications in infants.
Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.
Red discoloration of stools would appear when combined with iron supplements (Lancaster 2008).
Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.
Alternatives
We do not have alternatives for Cefdinir since it is relatively safe.
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Writings
- سافدينير (Arabic)
- Цефдинир (Cyrillic)
- 头孢地尼 (Chinese)
- セフジニル (Japanese)
- C14H13N5O5S2 (Molecular formula)
Drug trade names
References
- Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. 2013Abstract
- Lancaster J, Sylvia LM, Schainker E. Nonbloody, red stools from coadministration of cefdinir and iron-supplemented infant formulas. Pharmacotherapy. 2008Abstract
- Abbott. Omnicef. Drug Summary. 2007 Full text (in our servers)
- Bar-Oz B, Bulkowstein M, Benyamini L, Greenberg R, Soriano I, Zimmerman D, Bortnik O, Berkovitch M. Use of antibiotic and analgesic drugs during lactation. Drug Saf. 2003Abstract
- Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992Abstract