Is Cefoxitin Sodium compatible with breastfeeding? Do we have alternatives for Cefoxitin Sodium?

Cefoxitin Sodium

October 15, 2016 (Very Low Risk)

Second-generation cephalosporin for injection or parenteral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (references from Geddes 1977 to Zhang 1997).

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding

Alternatives

We do not have alternatives for Cefoxitin Sodium since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • Κεφοξιτίνη νατριούχος (Greek)
  • Натрий Цефокситин (Cyrillic)
  • セフォキシチンナトリウム (Japanese)
  • C16H16N3NaO7S2 (Molecular formula)

References

  1. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001Abstract Full text (link to original source) Full text (in our servers)
  2. Zhang Y, Zhang Q, Xu Z. [Tissue and body fluid distribution of antibacterial agents in pregnant and lactating women]. Zhonghua Fu Chan Ke Za Zhi. 1997Abstract
  3. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993Abstract
  4. Roex AJ, van Loenen AC, Puyenbroek JI, Arts NF. Secretion of cefoxitin in breast milk following short-term prophylactic administration in caesarean section. Eur J Obstet Gynecol Reprod Biol. 1987Abstract
  5. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984Abstract
  6. Dresse A, Lambotte R, Dubois M, Delapierre D, Kramp R. Transmammary passage of cefoxitin: additional results. J Clin Pharmacol. 1983Abstract
  7. Dubois M, Delapierre D, Chanteux L, Demonty J, Lambotte R, Kramp R, Dresse A. A study of the transplacental transfer and the mammary excretion of cefoxitin in humans. J Clin Pharmacol. 1981Abstract
  8. Brogden RN, Heel RC, Speight TM, Avery GS. Cefoxitin: a review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs 1979;17:1–37 1979
  9. Geddes AM, McGhie D, Ball AP, Gould I. Studies with cefuroxime and cefoxitin. Scand J Infect Dis Suppl. 1978Abstract
  10. Mashimo K, Mihashi S, Fukaya I, Okubo B, Ohgob M, Saito A. New drug symposium IV. Cefoxitin. Chemotherapy (Tokyo) 1978;26:114–9. 1978
  11. Takase Z, Shirafuji H, Uchida M. Clinical and laboratory studies on cefoxitin in the field of obstetrics and gynecology. Chemotherapy (Tokyo) 1978;26(Suppl 1):502–5. 1978
  12. Geddes AM, Schnurr LP, Ball AP, McGhie D, Brookes GR, Wise R, Andrews J. Cefoxitin: a hospital study. Br Med J. 1977Abstract Full text (link to original source) Full text (in our servers)