Is Cefpodoxime Proxetil compatible with breastfeeding? Do we have alternatives for Cefpodoxime Proxetil?

Cefpodoxime Proxetil

October 15, 2016 (Very Low Risk)

Third-generation cephalosporin for oral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (FDA 2013).

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

It has been reported a case of hyperprolactinemia and galactorrhea (Khurana 2010).

Alternatives

We do not have alternatives for Cefpodoxime Proxetil since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • Κεφποοξίμη προξετιλιωμένη (Greek)
  • Цефподоксима Проксетил (Cyrillic)
  • セフポドキシム プロキセチル (Japanese)
  • C21H27N5O9S2 (Molecular formula)

Drug trade names

References

  1. FDA. Cefpodoxime. Drug Summary. 2013 Full text (in our servers)
  2. AEMPS. Cefpodoxima. Ficha técnica. 2012 Full text (in our servers)
  3. Khurana V, Gambhir IS. Cefpodoxime-induced hyperprolactinemic galactorrhea. Ann Intern Med. 2010Abstract
  4. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993Abstract
  5. Saathoff N, Lode H, Neider K, Depperman KM, Borner K, Koeppe P. Pharmacokinetics of cefpodoxime proxetil and interactions with an antacid and an H2 receptor antagonist. Antimicrob Agents Chemother. 1992Abstract
  6. Tremblay D, Dupront A, Ho C, Coussediere D, Lenfant B. Pharmacokinetics of cefpodoxime in young and elderly volunteers after single doses. J Antimicrob Chemother. 1990Abstract