Cisapride
It is excreted into breast milk in clinically non-significant amount. No problems attributable to this drug have been observed among infants whose mothers were receiving this medication.
It may cause an increase of prolactin secretion.
American Academy of Pediatrics states that it is a medication usually compatible with breastfeeding.
Because of the high risk of QT-interval prolongation and cardiac arrhythmias in patients who are taking it, especially if other medicines are associated or patients are affected by other conditions, it has been withdrawn from the market in many countries.
Alternatives
- Metoclopramide (Very Low Risk)
- Domperidone (Very Low Risk)
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Writings
- Σιζαπρίδη μονοϋδρική (Greek)
- سيسابريد (Arabic)
- Цизаприд (Cyrillic)
- 西沙必利 (Chinese)
- シサプリド (Japanese)
- C23H29ClFN3O4,H2O (Molecular formula)
Drug trade names
References
- Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006Abstract Full text (link to original source) Full text (in our servers)
- AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001Abstract Full text (link to original source) Full text (in our servers)
- Hagemann TM. Gastrointestinal medications and breastfeeding. J Hum Lact. 1998Abstract
- Bennett JR. How safe and acceptable is cisapride? Scand J Gastroenterol Suppl. 1989Abstract
- Hofmeyr GJ, Sonnendecker EW. Secretion of the gastrokinetic agent cisapride in human milk. Eur J Clin Pharmacol. 1986Abstract