Is Clarithromycin compatible with breastfeeding? Do we have alternatives for Clarithromycin?

Clarithromycin

November 9, 2014 (Very Low Risk)

It is not excreted in significant amount into breast milk .

Commonly used for pediatric treatment which is very well tolerated.

Erythromycin is a macrolide that has been related to hypertrophic pyloric stenosis with early exposition. Avoiding use in the first post-partum month would be advisable yet it may occurred while breastfeeding.

Be aware of the possibility of false negative results of bacterial cultures when the mother is on antibiotics. Also, diarrheal disease due to imbalance of intestinal flora is possible.

Alternatives

We do not have alternatives for Clarithromycin since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Drug trade names

References

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  3. Maheshwai N. Are young infants treated with erythromycin at risk for developing hypertrophic pyloric stenosis? Arch Dis Child. 2007Abstract Full text (link to original source) Full text (in our servers)
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  8. Sedlmayr T, Peters F, Raasch W, Kees F. [Clarithromycin, a new macrolide antibiotic. Effectiveness in puerperal infections and pharmacokinetics in breast milk]. Geburtshilfe Frauenheilkd. 1993Abstract
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