Is Clebopride compatible with breastfeeding? Do we have alternatives for Clebopride?

Clebopride

March 27, 2015 (Low Risk)

Benzamide derivative agent which is similar to Metoclopramide but with higher extrapyramidal side-effects and poorly known pharmacokinetics.

At latest update, relevant published data on excretion into breast milk were not found.

As with Metoclopramide it produces increased secretion of Prolactin.

Until more data on this medication is available, safer alternative drugs are preferred, especially in such critical age periods.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • クレボプリド
  • LAS-9273
  • كليبوبريد
  • Клебоприд
  • 氯波必利

Drug trade names

References

  1. AEMPS. Cleboprida. Ficha técnica. 2014 Full text (in our servers)
  2. Serrano Serrano ME, Alvarez Frejo M, Tabernero García J, Martín Martín S. Síndrome extrapiramidal por cleboprida.\ [An extrapyramidal syndrome due to clebopride]. Aten Primaria. 1999Abstract Full text (link to original source) Full text (in our servers)
  3. Serrano Serrano ME, Alvarez Frejo M, Tabernero García J, Martín Martín S. [An extrapyramidal syndrome due to clebopride]. Aten Primaria. 1999Abstract
  4. Cuena Boy R, Maciá Martínez MA. Toxicidad extrapiramidal a metoclopramida y a cleboprida: estudio de las notificaciones voluntarias de reacciones adversas al Sistema Español de Farmacovigilancia.\ [Extrapyramidal toxicity caused by metoclopramide and clebopride: study of voluntary notifications of adverse effects to the Spanish Drug Surveillance System]. Aten Primaria. 1998Abstract Full text (link to original source) Full text (in our servers)
  5. Cuena Boy R, Maciá Martínez MA. [Extrapyramidal toxicity caused by metoclopramide and clebopride: study of voluntary notifications of adverse effects to the Spanish Drug Surveillance System]. Aten Primaria. 1998Abstract
  6. Jiménez-Jiménez FJ, Ortí-Pareja M, Ayuso-Peralta L, Gasalla T, Cabrera-Valdivia F, Vaquero A, Tejeiro J, García-Albea E. Drug-induced parkinsonism in a movement disorders unit: A four-year survey. Parkinsonism Relat Disord. 1996Abstract
  7. Perez-Lopez FR, Legido A, Sisskin M, Abos MD. Stimulatory effect of clebopride on human prolactin secretion. Fertil Steril. 1980Abstract