Clindamycin Topical
Lincosamide antibacterial. Anti-acne treatment drug.
Because a small dose and low plasma level found when topical preparations are used, locally applied products on skin do not have a significant excretion into breast milk. Less than 5% of the drug actually reach the blood plasma.
On the other hand, clindamycin is excreted in non-significant level intro breast milk with only few cases of enterocolitis in breastfed infants who cured spontaneously after discontinuation of drug.
Do not apply it on the breast or cleanse it thoroughly before nursing.
The American Academy of Pediatrics rates it as compatible with breastfeeding.
Alternatives
We do not have alternatives for Clindamycin Topical since it is relatively safe.
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Drug trade names
References
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- WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
- Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001Abstract
- AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001Abstract Full text (link to original source) Full text (in our servers)
- Borin MT, Ryan KK, Hopkins NK. Systemic absorption of clindamycin after intravaginal administration of clindamycin phosphate ovule or cream. J Clin Pharmacol. 1999Abstract
- van Hoogdalem EJ. Transdermal absorption of topical anti-acne agents in man; review of clinical pharmacokinetic data. J Eur Acad Dermatol Venereol. 1998Abstract
- Borin MT, Powley GW, Tackwell KR, Batts DH. Absorption of clindamycin after intravaginal application of clindamycin phosphate 2% cream. J Antimicrob Chemother. 1995Abstract
- Fulton B, Moore LL. Antiinfectives in breastmilk. Part II: Sulfonamides, tetracyclines, macrolides, aminoglycosides and antimalarials. J Hum Lact. 1992Abstract
- Borin MT. Systemic absorption of clindamycin following intravaginal application of clindamycin phosphate 1% cream. J Clin Pharmacol. 1990Abstract
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- Smith JA, Morgan JR, Rachlis AR, Papsin FR. Clindamycin in human breast milk. Can Med Assoc J. 1975Abstract Full text (in our servers)