Is Clobetasol Propionate compatible with breastfeeding? Do we have alternatives for Clobetasol Propionate?

Clobetasol Propionate

September 27, 2015 (Very Low Risk)

Topical corticosteroid with a very high strength.

At latest update it was not found published data on excretion into breast milk.
The small dose and poor absorption into plasma of most topical dermatological preparations make it unlikely any passage of significant amount in the breast milk.

If required to treat eczema or dermatitis of the nipple, it should be chosen lower strength steroids, apply it just after finishing the meal to let it be absorbed before the next meal, if necessary remove any excess with a gauze and avoid using it continuously for longer than a week.

Steroidal poisoning has occurred in an infant by continuous application of a corticosteroid in the nipple.

Avoid applying creams, gels and other products for local application on the nipple that contain paraffin (mineral oil) so that the baby does not absorb it.

Alternatives

We do not have alternatives for Clobetasol Propionate since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Clobetasol butyrate

Writings

  • Клобетазола Пропионат (Cyrillic)
  • クロベタゾールプロピオン酸エステル (Japanese)
  • C25 H32 ClFO5 (Molecular formula)

Drug trade names

References

  1. Barrett ME, Heller MM, Fullerton Stone H, Murase JE. Dermatoses of the breast in lactation. Dermatol Ther. 2013Abstract
  2. Westermann L, Hügel R, Meier M, Weichenthal M, Zillikens D, Gläser R, Schmidt E. Glucocorticosteroid-resistant pemphigoid gestationis: successful treatment with adjuvant immunoadsorption. J Dermatol. 2012Abstract
  3. Heller MM, Fullerton-Stone H, Murase JE. Caring for new mothers: diagnosis, management and treatment of nipple dermatitis in breastfeeding mothers. Int J Dermatol. 2012Abstract
  4. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008Abstract
  5. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003Abstract
  6. De Stefano P, Bongo IG, Borgna-Pignatti C, Severi F. Factitious hypertension with mineralocorticoid excess in an infant. Helv Paediatr Acta. 1983Abstract