Is Clomipramine compatible with breastfeeding? Do we have alternatives for Clomipramine?

Clomipramine

July 1, 2015 (Very Low Risk)

Excreted into breast milk in a clinically non-significant amount with no problems observed in breastfed infants from treated mothers.

Levels found in the plasma of those infants were very low or undetectable.

Because of a tiny excretion into the milk, symptoms due to deprivation syndrome would not be avoided by breastfeeding the infants whose mothers were taking this medication during pregnancy.

Galactorrhea out of the breastfeeding period has been described.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Clomipramine Hydrochloride
  • G-34586

Writings

  • Κλομιπραμίνη υδροχλωρική (Greek)
  • Кломипрамина Гидрохлорид (Cyrillic)
  • クロミプラミン塩酸塩 (Japanese)

Drug trade names

References

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  3. Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013Abstract Full text (link to original source) Full text (in our servers)
  4. Nielsen RE, Damkier P. Pharmacological treatment of unipolar depression during pregnancy and breast-feeding--a clinical overview. Nord J Psychiatry. 2012Abstract
  5. ter Horst PG, van der Linde S, Smit JP, den Boon J, van Lingen RA, Jansman FG, De Jong-van den Berg LT, Wilffert B. Clomipramine concentration and withdrawal symptoms in 10 neonates. Br J Clin Pharmacol. 2012Abstract Full text (link to original source) Full text (in our servers)
  6. Davanzo R, Copertino M, De Cunto A, Minen F, Amaddeo A. Antidepressant drugs and breastfeeding: a review of the literature. Breastfeed Med. 2011Abstract
  7. Sigma. Clomipramina. Ficha técnica. 2005 Full text (in our servers)
  8. Novartis. Clomipramine. Drug Summary. 2005 Full text (in our servers)
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  11. Yoshida K, Yamashita H. [Treatment strategy for women with puerperal psychiatric disorders--psychopharmaco-therapy and its impact on fetus and breast-fed infants]. Seishin Shinkeigaku Zasshi. 2003Abstract
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  13. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  14. Birnbaum CS, Cohen LS, Bailey JW, Grush LR, Robertson LM, Stowe ZN. Serum concentrations of antidepressants and benzodiazepines in nursing infants: A case series. Pediatrics. 1999Abstract Full text (link to original source) Full text (in our servers)
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