Is Clotrimazole compatible with breastfeeding? Do we have alternatives for Clotrimazole?


March 22, 2018 (Very Low Risk)

Excretion into breast milk is very unlikely since absorption through skin, vaginal mucosa, and, even intestinal mucosa into plasma is very poor with non-significant plasma levels or below the detection threshold (<10 ng/mL). In addition, because of a high plasma protein binding capacity, excretion into breast milk seems to be less likely.

It is used frequently for treatment of Candida infection, either in skin or mouth mucosa, even in newborn and premature infants without observed side-effects.

In case of use on the nipple, do it after feeding the baby and cleanse thoroughly the surface before the next one.

Do not use creams, gels and other locally applied products that contain paraffin (mineral oil) to prevent absorption by the infant.


We do not have alternatives for Clotrimazole since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.


  • Κλοτριμαζόλη (Greek)
  • كلوتريمازول (Arabic)
  • Клотримазол (Cyrillic)
  • 克霉唑 (Chinese)
  • クロトリマゾール (Japanese)
  • C22 H17 ClN2 (Molecular formula)
  • 1-(α-2-Chlorotrityl)imidazole (Chemical name)
  • A01AB18; D01AC01; G01AF02 (ATC Code/s)


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