Is Cyclobenzaprine compatible with breastfeeding? Do we have alternatives for Cyclobenzaprine?

Cyclobenzaprine

September 29, 2014 (Low Risk)

Relaxant drug of the muscle with action on the Central Nervous System and chemically related to tricyclic antidepressants.

At latest update, relevant information on excretion into breast milk was not found.

Because of a high plasma protein binding capacity, excretion into breast milk seems to be unlikely.

Long-term treatments or those mothers who are nursing a newborn or premature infant would be prudent the use of a known safer alternative or with a shorter elimination half life.

Infants should be monitored for sleepiness.

Alternatives

Carisoprodol (Low Risk probable)
Methocarbamol (Low Risk probable)

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

シクロベンザプリン

References

Brioschi TM, Schramm SG, Kano EK, Koono EE, Ching TH, Serra CH, Porta V. Pharmacokinetics and bioequivalence evaluation of cyclobenzaprine tablets. Biomed Res Int. 2013Abstract Full text (link to original source) Full text (in our servers)
MSyC-AgEspMedyPS. Ciclobenzaprina. Ficha técnica. 2013 Full text (in our servers)
Darwish M, Hellriegel ET. Steady-state pharmacokinetics of once-daily cyclobenzaprine extended release: a randomized, double-blind, 2-period crossover study in healthy volunteers. Clin Ther. 2011Abstract
Winchell GA, King JD, Chavez-Eng CM, Constanzer ML, Korn SH. Cyclobenzaprine pharmacokinetics, including the effects of age, gender, and hepatic insufficiency. J Clin Pharmacol. 2002Abstract
Till AE, Constanzer ML, Demetriades J, Irvin JD, Lee RB, Ferguson RK. Evidence for route dependent biotransformation of cyclobenzaprine hydrochloride. Biopharm Drug Dispos. 1982Abstract