Is Deflazacort compatible with breastfeeding? Do we have alternatives for Deflazacort?

Deflazacort

July 15, 2015 (Low Risk)

Drug which is oxazolinic-derived from Prednisolone with similar properties to the latter.

At latest update no published data on excretion into breast milk were found.

Due to a moderate high molecular weight and rapid elimination time it is probably safe while breastfeeding, mostly in non long-term treatments.
Until more data on this drug is available, it would be preferred other options that are known to be safer, specially during the neonatal period and prematurity.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Azacort
  • Oxazacort

Writings

  • ديفلازاكورت (Arabic)
  • Дефлазакорт (Cyrillic)
  • 地夫可特 (Chinese)
  • デフラザコルト (Japanese)
  • C25 H31 NO6 (Molecular formula)

Drug trade names

References

  1. eMC. Deflazacort. Drug Summary 2015 Full text (in our servers)
  2. AEMPS. Deflazacort. Ficha técnica. 2010 Full text (in our servers)
  3. Möllmann H, Hochhaus G, Rohatagi S, Barth J, Derendorf H. Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone. Pharm Res. 1995Abstract
  4. Barbieri C, Baruto C, Sala M, Bigatti G, Parodi M, Bellini P, Bevilacqua M. Lack of effect of deflazacort, a novel glucocorticoid, on basal and TRH-stimulated prolactin and thyrotropin levels in healthy subjects. Eur J Clin Pharmacol. 1985Abstract