Is Denosumab compatible with breastfeeding? Do we have alternatives for Denosumab?

Denosumab

July 2, 2015 (Low Risk)

Human-like monoclonal antibody IgG 2 that is used for treatment of severe of Osteoporosis and other disorders characterized by lost of bone mass.

At latest update, relevant published information on excretion into breast milk were not found.

Because of a high molecular weight, excretion into breast milk in significant amount is highly unlikely.

A low oral bioavailability makes absorption from the breast milk into infant's plasma to be seemingly nil or scanty, except for premature infants and in early post-natal period in which an increased absorption may occur.

Alternatives

We do not have alternatives for Denosumab.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • دينوسوماب (Arabic)
  • Денозумаб (Cyrillic)
  • 地舒单抗 (Chinese)
  • デノスマブ (Japanese)

Drug trade names

References

  1. PDR.NET Denosumab Drug summary 2014 Full text (in our servers)
  2. Bussiere JL, Pyrah I, Boyce R, Branstetter D, Loomis M, Andrews-Cleavenger D, Farman C, Elliott G, Chellman G. Reproductive toxicity of denosumab in cynomolgus monkeys. Reprod Toxicol. 2013Abstract
  3. Denosumab Ficha técnica 2011 Full text (in our servers)