Is Dipivefrine Hydrochloride compatible with breastfeeding? Do we have alternatives for Dipivefrine Hydrochloride?

Dipivefrine Hydrochloride

February 22, 2016 (Very Low Risk)

Ester and prodrug of epinephrine which is used as topical eye drops for treatment of glaucoma.

Because the small dose used and poor plasma absorption of most ophthalmic preparations it is unlikely the passage of significant amount into breast milk.
Absorption can be minimized by closing the eye after instillation and applying pressure for one minute with your finger on the tear duct at the inner corner of the eye.

A low oral bioavailability may hinder its passage to the infant's plasma from ingested milk.

Alternatives

We do not have alternatives for Dipivefrine Hydrochloride since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • Διπιβεφρίνη υδροχλωρική (Greek)
  • ديبيفيفرين (Arabic)
  • Дипивефрина Гидрохлорид (Cyrillic)
  • 地匹福林 (Chinese)
  • ジピベフリン塩酸塩 (Japanese)
  • C19H29NO5,HC (Molecular formula)

Drug trade names

References

  1. Ness T, Paulus W. [Ophthalmic agents during pregnancy and breastfeeding]. Ophthalmologe. 2012Abstract
  2. Bozhich M, Khentova-Senchanich P, Kontich J, Markovich V, Mar'ianovich I. [Glaucoma treatment during pregnancy and lactation]. Vestn Oftalmol. 2011Abstract
  3. Coppens G, Stalmans I, Zeyen T. Glaucoma medication during pregnancy and nursing. Bull Soc Belge Ophtalmol. 2010Abstract
  4. Labetoulle M, Gendron G, Offret H. [Eyedrops in children and pregnant or breast-feeding woman: why so many difficulties?]. J Fr Ophtalmol. 2009Abstract
  5. Madadi P, Koren G, Freeman DJ, Oertel R, Campbell RJ, Trope GE. Timolol concentrations in breast milk of a woman treated for glaucoma: calculation of neonatal exposure. J Glaucoma. 2008Abstract
  6. Johnson SM, Martinez M, Freedman S. Management of glaucoma in pregnancy and lactation. Surv Ophthalmol. 2001Abstract
  7. Mekki QA, Warrington SJ, Turner P. Bromocriptine eyedrops lower intraocular pressure without affecting prolactin levels. Lancet. 1984Abstract