Is Enoxolone compatible with breastfeeding? Do we have alternatives for Enoxolone?

Enoxolone

July 15, 2017 (Low Risk)

Glycyrrhizinic acid derivative that is extracted from the root of licorice.
Anti-inflammatory effect when topically applied (skin, mouth, throat and rectum).

At latest update no published data on excretion into breast milk were found.

It locally enhances the activity of hydrocortisone by inactivating a cortisol inhibiting enzyme, which can cause toxicity after systemic administration (see info on Licorice).
It is unknown the level of absorption after dermal and oral rinses or application, with a reported case of systemic toxicity following topical use. Hence, it is not recommended a prolonged use of this product during lactation.
It can cause contact dermatitis.

Avoid applying it on the breast, otherwise, clean it thoroughly before breastfeeding.


See below the information of this related product:

Alternatives

We do not have alternatives for Enoxolone.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Glycyrrhetic Acid (topical use)
  • Glycyrrhetinic Acid (topical (use)

Writings

  • إينوكسولون (Arabic)
  • Эноксолон (Cyrillic)
  • 甘草次酸 (Chinese)
  • グリチルレチン酸 (Japanese)
  • C30H46O4 (Molecular formula)

Drug trade names

References

  1. Omar HR, Komarova I, El-Ghonemi M, Fathy A, Rashad R, Abdelmalak HD, Yerramadha MR, Ali Y, Helal E, Camporesi EM. Licorice abuse: time to send a warning message. Ther Adv Endocrinol Metab. 2012Abstract Full text (link to original source)
  2. Navarre-Belhassen C, Cambonie G, Boluda C, Hillaire-Buys D. An unexpected case of primary pulmonary hypertension of the neonate (PPHN). Potential role of topical administration of enoxolone. J Perinat Med. 2002Abstract
  3. Tanaka S, Otsuki T, Matsumoto Y, Hayakawa R, Sugiura M. Allergic contact dermatitis from enoxolone. Contact Dermatitis. 2001Abstract
  4. Grassi A, Palermi G, Paradisi M. [Study of tolerance and efficacy of cosmetic preparations with lenitive action in atopic dermatitis in children]. Clin Ter. 2000Abstract
  5. MacKenzie MA, Hoefnagels WH, Kloppenborg PW. Glycyrrhetinic acid and potentiation of hydrocortisone activity in skin. Lancet. 1990Abstract