Is Erdosteine compatible with breastfeeding? Do we have alternatives for Erdosteine?

Erdosteine

June 10, 2018 (Low Risk)

A thiolactone derivative mucolytic agent of the natural amino acid homocysteine indicated in chronic obstructive bronchitis (CECMED 2017). Administered orally every 12 hours.

Since the last update we have not found published data on its excretion in breastmilk.

Its short half-life makes transfer to milk in significant quantities unlikely.

Side effects are gastrointestinal and mild.

This drug has very few bibliographic references and its effectiveness has not been proven (Cazzola 2018, Welsh 2015, Irwin 1993).

Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity.

If you wish to minimize exposure, you should wait about 3 hours to breastfeed after administration.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Homocysteine-Thiolactone

Writings

  • Ερδοστεΐνη (Greek)
  • إيردوستئين (Arabic)
  • Эрдостеин (Cyrillic)
  • 厄多司坦 (Chinese)
  • エルドステイン (Japanese)
  • Erdostéine (French)
  • C8 H11 NO4 S2 (Molecular formula)
  • (±)-({[(Tetrahydro-2-oxo-3-thienyl)carbamoyl]methyl}thio)acetic acid (Chemical name)
  • R05CB15 (ATC Code/s)

Drug trade names

References

  1. Cazzola M, Calzetta L, Page C, Rogliani P, Matera MG. Impact of erdosteine on chronic bronchitis and COPD: A meta-analysis. Pulm Pharmacol Ther. 2018Abstract
  2. CECMED. Erdosteína (Dostein). Ficha técnica. 2017 Full text (in our servers)
  3. Welsh EJ, Evans DJ, Fowler SJ, Spencer S. Interventions for bronchiectasis: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev. 2015Abstract
  4. Irwin RS, Curley FJ, Bennett FM. Appropriate use of antitussives and protussives. A practical review. Drugs. 1993Abstract