Is Eszopiclone compatible with breastfeeding? Do we have alternatives for Eszopiclone?

Eszopiclone

February 22, 2016 (Low Risk)

Isomer of zopiclone with similar hypnotic effects as benzodiazepines.
Used for insomnia.

At latest update no published data on excretion into breast milk were found.

Zopiclone is excreted in milk in non-significant amount.

Because the available published experience is poorer than with other drugs of the same group, it would be preferable an alternative and better known drug that would be considered safer, especially during the neonatal period and in case of prematurity.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Drug trade names

References

  1. FDA. Eszopiclone. Drug Summary. 2008 Full text (in our servers)
  2. Fernandez C, Martin C, Gimenez F, Farinotti R. Clinical pharmacokinetics of zopiclone. Clin Pharmacokinet. 1995Abstract
  3. Pons G, Rey E, Matheson I. Excretion of psychoactive drugs into breast milk. Pharmacokinetic principles and recommendations. Clin Pharmacokinet. 1994Abstract
  4. Matheson I, Sande HA, Gaillot J. The excretion of zopiclone into breast milk. Br J Clin Pharmacol. 1990Abstract
  5. Gaillot J, Heusse D, Hougton GW, Marc Aurele J, Dreyfus JF. Pharmacokinetics and metabolism of zopiclone. Pharmacology. 1983Abstract
  6. Gaillot J, Heusse D, Hougton GW, Marc Aurele J, Dreyfus JF. Pharmacokinetics and metabolism of zopiclone. Int Pharmacopsychiatry. 1982Abstract