Is Etamsylate compatible with breastfeeding? Do we have alternatives for Etamsylate?

Etamsylate

January 24, 2017 (Low Risk)

Hemostatic drug which has a possible protective effect on the capillary wall along with correction of altered platelet adhesion.
It is used in Menometrorrhagia (Lethaby 2013), prophylaxis on surgical wounds and neonatal intraventricular hemorrhage without a solid evidence of its effictiveness (Hunt 2010, Kuperman 2015).
It is orally, intramuscularly and intravenously administered.

At latest update relevant published data on excretion into breast milk were not found.

Its high capacity of binding to plasma proteins makes it unlikely a excretion into breast milk.

Due to low frequency and mildness of eventual side effects and/or absence of interference with coagulation mechanisms, seems unlikely this product would affect breastfeeding or the infant.

Alternatives

We do not have alternatives for Etamsylate.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Cyclonamine

Writings

  • Αιθαμσυλάτη (Greek)
  • إيتامسيلات (Arabic)
  • Этамзилат (Cyrillic)
  • 酚磺乙胺 (Chinese)
  • エタンシラート (Japanese)
  • C10H17NO5S (Molecular formula)

References

  1. Kuperman AA, Brenner B, Kenet G. Intraventricular haemorrhage in preterm infants--can we improve outcome by addressing coagulation? J Matern Fetal Neonatal Med. 2015Abstract
  2. Lethaby A, Duckitt K, Farquhar C. Non-steroidal anti-inflammatory drugs for heavy menstrual bleeding. Cochrane Database Syst Rev. 2013Abstract
  3. Unichima. Etamsylate. Drug Summary. 2012 Full text (in our servers)
  4. AEMPS. Etamsilato. Ficha técnica. 2010 Full text (in our servers)
  5. MEPPO. Etamsylate Drug Summary. 2010 Full text (in our servers)
  6. Hunt R, Hey E. Ethamsylate for the prevention of morbidity and mortality in preterm or very low birth weight infants. Cochrane Database Syst Rev. 2010Abstract
  7. Arora YR, Manford ML. Operative blood loss and the frequency of haemorrhage associated with adenotonsillectomy in children: a double-blind trial of ethamsylate. Br J Anaesth. 1979Abstract