Is Flucloxacillin compatible with breastfeeding? Do we have alternatives for Flucloxacillin?

Flucloxacillin

July 2, 2015 (Very Low Risk)

Like most penicillin-type antibiotics, excretion into breast milk is clinically non-significant. No harmful effects have been found among breastfed infants from treated mothers.

Widely used for treatment of Mastitis since it has an effective activity against Staphylococcus.

Be aware of false negative results of microbial cultures done from samples of febrile infants whose mothers are treated with antibiotics. Also, due to imbalance of intestinal flora a diarrheal disease can occur in the breastfed infant.

List of Essential Medicines by WHO 2002: compatible with breastfeeding.

Alternatives

We do not have alternatives for Flucloxacillin since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • Floxacillin

Writings

  • فلوكلوكساسيلين (Arabic)
  • Флуклоксациллин (Cyrillic)
  • 氟氯西林 (Chinese)
  • フロキサシリン (Japanese)

References

  1. Amir LH. ABM Clinical Protocol #4: Mastitis, Revised March 2014. Breastfeed Med. 2014Abstract Full text (link to original source) Full text (in our servers)
  2. Spencer JP. Management of mastitis in breastfeeding women. Am Fam Physician. 2008Abstract Full text (link to original source) Full text (in our servers)
  3. Academy of Breastfeeding Medicine Protocol Committee. ABM clinical protocol #4: mastitis. Revision, May 2008. Breastfeed Med. 2008Abstract
  4. Nordeng H, Tufte E, Nylander G. [Treatment of mastitis in general practice]. Tidsskr Nor Laegeforen. 2003Abstract
  5. Bodley V, Powers D. Case management of a breastfeeding mother with persistent oversupply and recurrent breast infections. J Hum Lact. 2000Abstract
  6. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993Abstract
  7. Ogle KS, Davis S. Mastitis in lactating women. J Fam Pract. 1988Abstract
  8. Dixon JM. Repeated aspiration of breast abscesses in lactating women. BMJ. 1988Abstract Full text (link to original source) Full text (in our servers)
  9. Nau H. Clinical pharmacokinetics in pregnancy and perinatology. II. Penicillins. Dev Pharmacol Ther. 1987Abstract
  10. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984Abstract