Is Fluconazole compatible with breastfeeding? Do we have alternatives for Fluconazole?

Fluconazole

March 22, 2018 (Very Low Risk)

Excreted into breast milk in much lesser amount than that used for the treatment of Candida infection in the infant. Problems have not appeared in breastfed infants from treated mothers.

Widely used for the treatment of breast pain due or allegedly due to Candida infection. In those cases of breast candidiasis where topical treatment fails, oral Fluconazole may be used at a dose of 200 mg for the first day to be followed by 100 mg daily for two weeks.

The American Academy of Pediatrics rates it compatible with breastfeeding.

Alternatives

We do not have alternatives for Fluconazole since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • Φλουκοναζόλη (Greek)
  • فلوكونازول (Arabic)
  • Флуконазол (Cyrillic)
  • 氟康唑 (Chinese)
  • フルコナゾール (Japanese)
  • C13 H12 F2 N6 O (Molecular formula)
  • 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol (Chemical name)
  • D01AC15; J02AC01 (ATC Code/s)

Drug trade names

References

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  2. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011Abstract Full text (link to original source) Full text (in our servers)
  3. Pereira CA, da Costa AC, Machado AK, Beltrame Júnior M, Zöllner MS, Junqueira JC, Jorge AO. Enzymatic activity, sensitivity to antifungal drugs and Baccharis dracunculifolia essential oil by Candida strains isolated from the oral cavities of breastfeeding infants and in their mothers' mouths and nipples. Mycopathologia. 2011Abstract
  4. Hanna L, Cruz SA. Candida mastitis: a case report. Perm J. 2011Abstract Full text (link to original source) Full text (in our servers)
  5. Moorhead AM, Amir LH, O'Brien PW, Wong S. A prospective study of fluconazole treatment for breast and nipple thrush. Breastfeed Rev. 2011Abstract
  6. Chen LH, Zeind C, Mackell S, LaPointe T, Mutsch M, Wilson ME. Breastfeeding travelers: precautions and recommendations. J Travel Med. 2010Abstract Full text (link to original source) Full text (in our servers)
  7. Stamatakos M, Kontzoglou K, Sargedi C, Tsaknaki S, Safioleas M. Mammary candidiasis. A breast infection difficult to handle. Chirurgia (Bucur). 2008Abstract
  8. Carmichael AR, Dixon JM. Is lactation mastitis and shooting breast pain experienced by women during lactation caused by Candida albicans? Breast. 2002Abstract
  9. Chetwynd EM, Ives TJ, Payne PM, Edens-Bartholomew N. Fluconazole for postpartum candidal mastitis and infant thrush. J Hum Lact. 2002Abstract
  10. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  11. Brent NB. Thrush in the breastfeeding dyad: results of a survey on diagnosis and treatment. Clin Pediatr (Phila). 2001Abstract
  12. Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001Abstract
  13. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001Abstract Full text (link to original source) Full text (in our servers)
  14. Hoover K. Breast pain during lactation that resolved with fluconazole: two case studies. J Hum Lact. 1999Abstract
  15. Bodley V, Powers D. Long-term treatment of a breastfeeding mother with fluconazole-resolved nipple pain caused by yeast: a case study. J Hum Lact. 1997Abstract
  16. Debruyne D. Clinical pharmacokinetics of fluconazole in superficial and systemic mycoses. Clin Pharmacokinet. 1997Abstract
  17. Force RW. Fluconazole concentrations in breast milk. Pediatr Infect Dis J. 1995Abstract
  18. Dhondt F, Ninane J, De Beule K, Dhondt A, Cauwenbergh G. Oral candidosis: treatment with absorbable and non-absorbable antifungal agents in children. Mycoses. 1992Abstract