Is Fluvoxamine compatible with breastfeeding? Do we have alternatives for Fluvoxamine?

Fluvoxamine

July 1, 2015 (Very Low Risk)

It is excreted into breast milk in non-significant amount. Plasma level in infants from mother who receive Fluvoxamine is usually undetectable. Not effects on the infant's physical and psychomotor development at both short or long-term were found.

Because there is less experience published than with other antidepressants of the same pharmacological group, it should be preferred the use of an alternative drug that is known to be safer in the neonatal period or prematurity.

Galactorrhea has been observed but less frequently than with other antidepressants.

In cases of treatment with xanthines (theophylline, caffeine) for apnea of prematurity, the plasma level of them should be monitored because Fluvoxamine is a strong inhibitor of activity of the Cytochrome P450-CYP1A2 which is responsible for metabolic elimination of xanthines.

Women who use antidepressant medication during pregnancy are in need of more support for breastfeeding since they are at risk for early weaning.

Alternatives

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Synonyms

  • DU-23000
  • Fluvoxamine Maleate

Writings

  • Флувоксамина Малеат (Cyrillic)
  • フルボキサミンマレイン酸塩 (Japanese)

Drug trade names

References

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