Is Fosfomycin compatible with breastfeeding? Do we have alternatives for Fosfomycin?

Fosfomycin

June 30, 2015 (Very Low Risk)

Excretion into breast milk is not significant and no side effects on breastfed infants of treated mothers have been shown.

Approved for use as treatment on infants younger than a one year old.

A low oral bioavailability would protect the infant, except in the neonatal period or cases of prematurity. Calcium contained in the milk prevents it from absorption by the gut.

Be aware of the possibility of false negative results of bacterial cultures on febrile infants when the mother is on antibiotics.

Alternatives

We do not have alternatives for Fosfomycin since it is relatively safe.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Writings

  • فوسفوميسين (Arabic)
  • Фосфомицин (Cyrillic)
  • 磷霉素 (Chinese)
  • ホスホマイシン (Japanese)

References

  1. PDR.net Fosfomycin Drug Summary 2014 Full text (in our servers)
  2. Gobernado M. [Fosfomycin]. Rev Esp Quimioter. 2003Abstract Full text (link to original source) Full text (in our servers)
  3. AEMPS Fosfomicina Ficha técnica 2003 Full text (in our servers)
  4. Mactal-Haaf C, Hoffman M, Kuchta A. Use of anti-infective agents during lactation, Part 3: Antivirals, antifungals, and urinary antiseptics. J Hum Lact. 2001Abstract
  5. Bergan T, Thorsteinsson SB, Albini E. Pharmacokinetic profile of fosfomycin trometamol. Chemotherapy. 1993Abstract
  6. Bergan T. Pharmacokinetic comparison between fosfomycin and other phosphonic acid derivatives. Chemotherapy. 1990Abstract
  7. Bergan T. Degree of absorption, pharmacokinetics of fosfomycin trometamol and duration of urinary antibacterial activity. Infection. 1990Abstract
  8. Kirby WM. Pharmacokinetics of fosfomycin. Chemotherapy. 1977Abstract