Is Ganirelix Acetate compatible with breastfeeding? Do we have alternatives for Ganirelix Acetate?

Ganirelix Acetate

January 26, 2014 (Low Risk)

Competitive gonadotropin-releasing hormone antagonist. Ganirelix accetate is used for treatment of female infertility by ovarian stimulation.

On latest update relevant data on breastfeeding was not found.

A high molecular weight makes excretion into breast milk unlikely.

Because its protein composition it would not be absorbed by the gut. A low oral biodisponibility prevents it from absorption by the breastfed child except in case of prematurity and newborn period.

Alternatives

We do not have alternatives for Ganirelix Acetate.

Very Low Risk

Compatible. Not risky for breastfeeding or infant.

Low Risk

Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.

High Risk

Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.

Very High Risk

Not recommended. Cessation of breastfeeding or alternative.

Drug trade names

References

  1. Ganirelix Ficha técnica 2013 Full text (in our servers)
  2. Ganirelix Drug Summary 2013 Full text (in our servers)
  3. Oberyé JJ, Mannaerts BM, Kleijn HJ, Timmer CJ. Pharmacokinetic and pharmacodynamic characteristics of ganirelix (Antagon/Orgalutran). Part I. Absolute bioavailability of 0.25 mg of ganirelix after a single subcutaneous injection in healthy female volunteers. Fertil Steril. 1999Abstract