Guaifenesin
It is used as an expectorant, alone or in association with other products. Proofs on its effectiveness are sparse. In some instances, preparations of Guaifenesin may contain alcohol as excipient with a concentration as high as 5%.
At latest update, relevant published data on excretion into breast milk were not found.
Until more information on this medication is available, other option known to be safer would be recommended, mostly in the post-natal period or in cases of prematurity.
If used while breastfeeding, a moderate use with the lowest dose as possible and avoiding those preparations with alcoholic excipient, should be preferred.
Because effectiveness is poor and likelihood of side effects does exist, especially in multi-association, the US Agency for Drug Administration (FDA) is currently doing efforts for discontinuation of this and others at-the-counter products, that are formulated for cough relief (Guaifenesin, Dextromethorphan, Phenylephrine, Pseudoephedrine, Brompheniramine, etc.)
Alternatives
- Acetylcysteine (Very Low Risk)
- Ambroxol (Very Low Risk)
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Synonyms
- グアイフェネシン
- Guaiacol Glycerol Ether
- غوائيفينيسين
- Γουαϊφενεσίνη
- Гвайфенезин
- 愈创甘油醚
Drug trade names
- Coldrex Broncho (Колдрекс Бронхо)™
- Dimetapp Expectorante™ (Brazil)
- Fagusan™
- Formulaexpec™
- Frispec™
- Guaifen™
- Mucinex™
- Novo-Passit (Ново-Пассит)™
- Numonyl Jarabe™
- Omega 100 Bronquial™
- Organidin NR™
- Plenum™
- Robitussin™
- Theraflu KV (Терафлю КВ)™
- Tussin (Туссин)™
- Vick 44 Exp™
- Vickmiel™
- Vicks Cough Syrup for Chesty Cough™
- VP-Syrup™
- Wick Husten-Loser™
- ВІКС АКТИВ МЕДЕКСПЕКТО
- ГВАЙФЕНЕЗИН
- ГУАЙФЕНЕЗИН
References
- Smith SM, Schroeder K, Fahey T. Over-the-counter (OTC) medications for acute cough in children and adults in community settings. Cochrane Database Syst Rev. 2014Abstract
- AEMPS. Guaifenesina. Ficha técnica. 2013 Full text (in our servers)
- Guaifenesin. Drug Summary. 2012 Full text (in our servers)
- REis AMM, Figueras A. Analysis of the evidence of efficacy and safety of over-the-counter cough medications registered in Brazil. Brazilian Journal of Pharmaceutical Sciences, 46: 1. 2010 Full text (in our servers)
- Bolser DC. Cough suppressant and pharmacologic protussive therapy: ACCP evidence-based clinical practice guidelines. Chest. 2006Abstract Full text (link to original source) Full text (in our servers)
- Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000Abstract