Hexetidine
A bactericidal and fungicidal antiseptic.
Used topically in mild mucus infections (vaginal, 0.1% mouthwash for oral hygiene).
Since the last update we have not found published data on its excretion in breast milk.
The small dose and low plasma absorption of most topical preparations make it unlikely that significant amounts will be transferred into breastmilk, as stated in information for hexetidine (McNeil Products Ltd 2017).
A case of contact dermatitis has been documented following its use (Merk 1982), so contact should be avoided with mucous membranes or the baby’s skin.
As an oral antiseptic it is much less effective than chlorhexidine (Afennich 2011).
Alternatives
- Chlorhexidine (Very Low Risk)
Very Low Risk
Compatible. Not risky for breastfeeding or infant.
Low Risk
Moderately safe. Mild risk possible. Follow up recommended. Read the Comment.
High Risk
Poorly safe. Evaluate carefully. Use a safer alternative. Read the Comment.
Very High Risk
Not recommended. Cessation of breastfeeding or alternative.
Writings
- Εξετιδίνη (Greek)
- هيكزيتيدين (Arabic)
- Гексэтидин (Cyrillic)
- 海克替啶 (Chinese)
- ヘキセチジン (Japanese)
- Hexétidine (French)
- C21H45N3 (Molecular formula)
- 5-Amino-1,3-bis(2-ethylhexyl)hexahydro-5-methylpyrimidine (Chemical name)
- A01AB12 (ATC Code/s)
- G01AX16 (ATC Code/s)
Drug trade names
References
- McNeil Products Ltd. Oraldene (Hexetidine). Drug Summary. 2017 Full text (in our servers)
- Afennich F, Slot DE, Hossainian N, Van der Weijden GA. The effect of hexetidine mouthwash on the prevention of plaque and gingival inflammation: a systematic review. Int J Dent Hyg. 2011Abstract
- Parke Davis. Hexetidina. Ficha técnica. 2000 Full text (in our servers)
- Merk H, Ebert L, Goerz G. Allergic contact dermatitis due to the fungicide hexetidine. Contact Dermatitis. 1982Abstract